Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study (IP4)
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ClinicalTrials.gov Identifier: NCT01937065
Recruitment Status : Unknown
Verified September 2013 by Harry Hemingway, University College, London. Recruitment status was: Active, not recruiting
First Posted : September 9, 2013
Last Update Posted : September 9, 2013
University College, London
National Institute for Health Research, United Kingdom
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases. [ Time Frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years ]
by age group
in high risk groups (smokers, hypertensive disease, obese, diabetic, depression)
before and after the introduction of the Quality and Outcomes Framework in England
Secondary Outcome Measures :
Lifetime cumulative incidence per quintile of social deprivation [ Time Frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years ]
Other Outcome Measures:
Heterogeneity in associations across 12 cardiovascular diseases using the Tau-squared statistic and I-square statistics. [ Time Frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years ]
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Ages Eligible for Study:
30 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
1,93 million patients registered in Clinical Practice Research Datalink (CPRD) practices
One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
30 years or older
Free of symptomatic CVD at inclusion.
Pregnant women in the 6 months before the eligibility date