Analysis of Remote-ischemic Preconditioning Effects on Kidney Function (RenPRO-TAVI)
Patients with impaired renal function are at elevated risk for development of acute kidney injury (AKI). AKI is associated with increased risk for cardiovascular morbidity and mortality. Effective AKI prevention strategies are needed. Remote ischemic preconditioning (RIPC) is a novel and successful strategy to attenuate contrast medium induced AKI in patients undergoing elective coronary angiography.
The retrospective RenPro-TAVI Trial was designed to test the hypothesis whether remote ischemic preconditioning might attenuate kidney injury in patients receiving transcatheter aortic valve implantation (TAVI).
Patients with impaired renal function undergoing TAVI will be evaluated in respect whether they received remote ischemic preconditioning before the procedure or not. This study will give insight if RIPC might be beneficial in these patients.
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Remote Ischemic Preconditioning Effects on Kidney Function in Patients Receiving Transcatheter Aortic Valve Implantation|
- change in parameters determining renal function and injury [ Time Frame: 48 hours after TAVI ]serum creatinine, cystatin c, urinary neutrophil gelatinase-associated lipocalin (NGAL)
- acute kidney injury [ Time Frame: 48 hours after TAVI ]increase in serum creatinine ≥25% or ≥0.5 mg/dL above baseline at 48 hours after TAVI
|Study Start Date:||March 2010|
|Study Completion Date:||July 2011|
|Primary Completion Date:||July 2011 (Final data collection date for primary outcome measure)|
patients with impaired renal function and a high risk of developing acute kidney injury undergoing TAVI and receiving standard care including pre-hydration 12 hours prior and 12 hours post procedure
patients with impaired renal function and a high risk of developing acute kidney injury undergoing TAVI and receiving standard care including pre-hydration 12 hours prior and 12 hours post procedure plus ischemic preconditioning (intermittent arm ischemia through 4 cycles of 5-minute inflation and 5-minute deflation of a blood pressure cuff)
Procedure: remote ischemic preconditioning
Other Name: intermittent arm ischemia through 4 cycles of 5-minute inflation and 5-minute deflation of a blood pressure cuff
Please refer to this study by its ClinicalTrials.gov identifier: NCT01925235
|University Hospital of Cologne|
|Cologne, NRW, Germany, 50931|