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Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial

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ClinicalTrials.gov Identifier: NCT01897350
Recruitment Status : Completed
First Posted : July 12, 2013
Last Update Posted : October 21, 2014
Information provided by (Responsible Party):
Elisa McAlindon, University of Bristol

Brief Summary:
Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.

Condition or disease Intervention/treatment
ST Segment Elevation Myocardial Infarction Myocardial Oedema Other: Cardiac magnetic resonance imaging

Study Type : Observational
Actual Enrollment : 30 participants
Time Perspective: Prospective
Study Start Date : July 2013
Primary Completion Date : December 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Edema Heart Attack
U.S. FDA Resources

Group/Cohort Intervention/treatment
CMR following ST segment myocardial infarction Other: Cardiac magnetic resonance imaging

Primary Outcome Measures :
  1. The mass of myocardial oedema measured by CMR [ Time Frame: Day 2 following STEMI ]

Secondary Outcome Measures :
  1. Extra cellular volume [ Time Frame: Day 2 following STEMI ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
30 patients will be undergo a CMR scan day 2 following STEMI

Inclusion Criteria:

  • providing written informed consent

Exclusion Criteria:

  • contraindication to CMR,
  • atrial fibrillation,
  • claustrophobia,
  • eGFR < 30

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01897350

United Kingdom
Bristol Heart Institute
Bristol, Avon, United Kingdom, BS2 8HW
Sponsors and Collaborators
Elisa McAlindon

Responsible Party: Elisa McAlindon, principle investigator, University of Bristol
ClinicalTrials.gov Identifier: NCT01897350     History of Changes
Other Study ID Numbers: Study 1953
First Posted: July 12, 2013    Key Record Dates
Last Update Posted: October 21, 2014
Last Verified: October 2014

Keywords provided by Elisa McAlindon, University of Bristol:
Myocardial edema
Cardiovascular magnetic resonance

Additional relevant MeSH terms:
Myocardial Infarction
ST Elevation Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Signs and Symptoms