The Flashing Light-Induced Pupil Response (FLIPR) Glaucoma Study (FLIPR)
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|ClinicalTrials.gov Identifier: NCT01857440|
Recruitment Status : Completed
First Posted : May 20, 2013
Last Update Posted : September 25, 2017
|Condition or disease|
|Glaucoma, Open-Angle Eye Diseases|
The pupils inside the eyes constrict in response to light stimulation. Different classes of cells within the human retina initiate this response. Recent research suggests that one of the ganglion cell types involved in this pupil response is affected by glaucoma. By measuring pupil responses to different colored lights, the function of this class of cells can be evaluated quickly, and without touching the eye. An advantage of pupil testing strategies is that they do not require subjective feedback from the subject about what they can see, as is required for standard visual field tests that are used in the clinic.
The main aim of this study is to measure and compare the pupil constriction that occurs in response to flickering red and blue lights in patients with glaucoma versus matched control patients without glaucoma. In addition, the subjects will be asked questions about their quality of life and it will be determined whether issues related to quality of life correlate to alterations in the pupil responses.
|Study Type :||Observational|
|Actual Enrollment :||32 participants|
|Official Title:||The Flashing Light-Induced Pupil Response (FLIPR) Glaucoma Study|
|Study Start Date :||May 2013|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2015|
Subjects with glaucoma (Cases)
This group will consist of patients with glaucoma who are under care at the Ohio State University Havener Eye Institute.
Subjects without glaucoma (Controls)
This group will consist of matched controls who are free of glaucoma and other complications, and who received a comprehensive eye examination at the Ohio State University College of Optometry.
- Pupil Response [ Time Frame: Single Visit: One Day ]Using fourier analysis, the pupil fluctuation evoked by blue and red flickering lights will be measured in glaucoma patients and compared to matched controls.
- Quality of Life Survey [ Time Frame: Single Visit: One Day ]Subjects will fill out a questionnaire with questions that assess quality of life issues, and the results will be correlated to the pupil response data.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01857440
|United States, Ohio|
|OSU College of Optometry|
|Columbus, Ohio, United States, 42310|
|Havener Eye Institute|
|Columbus, Ohio, United States, 43212|
|Principal Investigator:||Andrew Hartwick, OD, PhD||OSU College of Optometry|