The Effect of Weight Loss on Ovarian Reserve

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01844128
Recruitment Status : Unknown
Verified April 2013 by Amir Wiser, Meir Medical Center.
Recruitment status was:  Recruiting
First Posted : May 1, 2013
Last Update Posted : June 11, 2013
Information provided by (Responsible Party):
Amir Wiser, Meir Medical Center

Brief Summary:

Obesity affects on fertility. Obese women have lower pregnancy rate after infertility treatments.They need more doses of hormone during ovarian stimulation, more days for stimulation. During IVF treatment less oocytes are collected and the quality of embryo also harmed.

The first line treatment for those women with obesity and infertility is weight loss.

The investigators' hypothesis is that weight reduction improves ovarian reserve and fertility treatment outcome.

Condition or disease Intervention/treatment
Weight Loss Dietary Supplement: weight loss

Detailed Description:
The investigators have outpatient clinic for obesity and infertility. the patients undergoing program of 3 months with diet and physical activity. Blood sample will take at the beginning of the program and at the end. The blood sample will evaluate for: AMH, Adiponectin, Leptin, CRP, Colesterol, CRP, Smac in addition TVUS will perform to evaluate AFC.

Study Type : Observational [Patient Registry]
Estimated Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 1 Year
Study Start Date : May 2013
Estimated Primary Completion Date : April 2014

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort Intervention/treatment
overweight women with infertility Dietary Supplement: weight loss

Primary Outcome Measures :
  1. Anti Mullerain Hormone (AMH)and AFC before and after weight loss [ Time Frame: 3 months ]
    AMH and AFC will measure at the first visit and after 3 months of weight loss program

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 43 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Overweight women with infertility

Inclusion Criteria:

  • undergoing weight loss program

Exclusion Criteria:

  • dropp out before comletion the weighy loss target

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01844128

Contact: Amir Wiswe, MD +97297472227

Meir Medical Center Recruiting
Kfar Sava, Israel
Contact: Overweight &Infertility clinic    097471555      
Principal Investigator: Amir Wiser, MD         
Sponsors and Collaborators
Meir Medical Center

Responsible Party: Amir Wiser, Senior physician IVF Unit, Meir Medical Center Identifier: NCT01844128     History of Changes
Other Study ID Numbers: 0257-12mmc
First Posted: May 1, 2013    Key Record Dates
Last Update Posted: June 11, 2013
Last Verified: April 2013

Keywords provided by Amir Wiser, Meir Medical Center:
MMA, AFC, Ovarian reserve

Additional relevant MeSH terms:
Weight Loss
Body Weight Changes
Body Weight
Signs and Symptoms