Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
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|ClinicalTrials.gov Identifier: NCT01840839|
Recruitment Status : Completed
First Posted : April 26, 2013
Last Update Posted : January 30, 2018
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|Condition or disease||Intervention/treatment||Phase|
|Older Adults (50-90 Years)||Device: brain stimulation Device: Sham Stimulation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||18 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep in Older Adults|
|Study Start Date :||October 2013|
|Actual Primary Completion Date :||May 2015|
|Actual Study Completion Date :||August 2015|
Experimental: 0,75 Hz stimulation
transcranial slow oscilliating stimulation (tSOS)during periods of SWS
Device: brain stimulation
Other Name: oscillating direct current brain stimulation
Sham Comparator: no stimulation
Sham stimulation during periods of SWS
Device: Sham Stimulation
Other Name: no stimulation
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [ Time Frame: 4 weeks ]Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
- 1. Amount of Slow wave Sleep [ Time Frame: 4 weeks ]1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- 2. sleep spindels [ Time Frame: 4 weeks ]2.Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- 3. EEG-correlates [ Time Frame: 4 weeks ]3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- 4. further memory systems [ Time Frame: 4 weeks ]4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
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|Ages Eligible for Study:||50 Years to 90 Years (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
- age: 50-90 years
- right handed
- inobtrusive neuropsychological examination
- untreated severe internal or psychiatric diseases
- other severe neurological diseases eg., previous major stroke, brain tumour
- contraindications to MRI
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01840839
|Charite CCM Neurologie Berlin|
|Berlin, Germany, 10117|
|Study Chair:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|
|Principal Investigator:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:||Agnes Flöel, Prof. Agnes Flöel, MD, Charite University, Berlin, Germany|
|Other Study ID Numbers:||
|First Posted:||April 26, 2013 Key Record Dates|
|Last Update Posted:||January 30, 2018|
|Last Verified:||January 2018|