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Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults

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ClinicalTrials.gov Identifier: NCT01840839
Recruitment Status : Completed
First Posted : April 26, 2013
Last Update Posted : January 30, 2018
Information provided by (Responsible Party):
Agnes Flöel, Charite University, Berlin, Germany

Brief Summary:
The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects. Slow wave sleep (SWS), in particular, with its slow oscillating activity have shown to enhance declarative, hippocampus-dependent memory representations. This impact of sleep on memory performance can be additionally enhanced by exogeneous induction of transcranial slow oscillating stimulation (tSOS) within the frequency range of SWS in humans (0,7- 0,8 Hz) during sleep, as has been demonstrated in young, healthy subjects. If older adults that commonly experiencing cognitive decline, including long-term retention of declarative memory - benefit from transcranial slow oscillatory stimulation (tSOS) during sleep in the same way has not been studied so far. The primary goal of the study is therefore to investigate the impact of oscillating current stimulation (tSOS) during a daytime nap on declarative memory consolidation in older adults.

Condition or disease Intervention/treatment Phase
Older Adults (50-90 Years) Device: brain stimulation Device: Sham Stimulation Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 18 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep in Older Adults
Study Start Date : October 2013
Actual Primary Completion Date : May 2015
Actual Study Completion Date : August 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory

Arm Intervention/treatment
Experimental: 0,75 Hz stimulation
transcranial slow oscilliating stimulation (tSOS)during periods of SWS
Device: brain stimulation
Other Name: oscillating direct current brain stimulation

Sham Comparator: no stimulation
Sham stimulation during periods of SWS
Device: Sham Stimulation
Other Name: no stimulation

Primary Outcome Measures :
  1. Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [ Time Frame: 4 weeks ]
    Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.

Secondary Outcome Measures :
  1. 1. Amount of Slow wave Sleep [ Time Frame: 4 weeks ]
    1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.

  2. 2. sleep spindels [ Time Frame: 4 weeks ]
    2.Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.

  3. 3. EEG-correlates [ Time Frame: 4 weeks ]
    3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).

  4. 4. further memory systems [ Time Frame: 4 weeks ]
    4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.

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Ages Eligible for Study:   50 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age: 50-90 years
  • right handed
  • inobtrusive neuropsychological examination

Exclusion Criteria:

  • untreated severe internal or psychiatric diseases
  • epilepsy
  • other severe neurological diseases eg., previous major stroke, brain tumour
  • dementia
  • contraindications to MRI

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01840839

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Charite CCM Neurologie Berlin
Berlin, Germany, 10117
Sponsors and Collaborators
Charite University, Berlin, Germany
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Study Chair: Agnes Flöel, Professor Charite Universitätsmedizin Berlin - Neurologie
Principal Investigator: Agnes Flöel, Professor Charite Universitätsmedizin Berlin - Neurologie
Publications of Results:
Other Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Agnes Flöel, Prof. Agnes Flöel, MD, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier: NCT01840839    
Other Study ID Numbers: Nap-tSOS-aged
First Posted: April 26, 2013    Key Record Dates
Last Update Posted: January 30, 2018
Last Verified: January 2018
Keywords provided by Agnes Flöel, Charite University, Berlin, Germany:
cognitive decline
brain stimulation
daytime sleep
memory consolidation