Adiponectin and Ethnic Differences in Insulin Resistance

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01831102
Recruitment Status : Completed
First Posted : April 15, 2013
Last Update Posted : April 15, 2013
Information provided by (Responsible Party):
University of Colorado, Denver

Brief Summary:
The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.

Condition or disease Intervention/treatment
Insulin Resistance Type 2 Diabetes Other: none- observational study

Study Type : Observational
Actual Enrollment : 43 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Adiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance
Study Start Date : March 2011
Actual Primary Completion Date : August 2011
Actual Study Completion Date : August 2011

Resource links provided by the National Library of Medicine

Drug Information available for: Insulin

Group/Cohort Intervention/treatment
non-Latino white
no Latino ancestry, Caucasian
Other: none- observational study
Mexican American
Mexican American ancestry
Other: none- observational study

Primary Outcome Measures :
  1. total adiponectin concentration [ Time Frame: measured once during second study visit, in fasting condition ]

Secondary Outcome Measures :
  1. Insulin sensitivity [ Time Frame: Measured once, during second study visit. ]
    Calculated from insulin and glucose values obtained during IV glucose tolerance test.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample

Inclusion Criteria:

  • 18-60 years of age
  • BMI 20.0-34.9 m/kg2
  • Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

Exclusion Criteria:

  • pregnancy
  • breastfeeding
  • diabetes mellitus
  • blood pressure > 160/100 mmHg
  • creatinine > 1.5 mg/dl or glomerular filtration rate (GFR) < 60
  • liver function tests > 3x upper limit of normal (ULN)
  • h/o heart failure
  • h/o eating disorder

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01831102

United States, Colorado
University of Colorado Anschutz Medical Center
Aurora, Colorado, United States, 80045
Sponsors and Collaborators
University of Colorado, Denver
Principal Investigator: Rocio Pereira, MD University of Colorado, Denver

Responsible Party: University of Colorado, Denver Identifier: NCT01831102     History of Changes
Other Study ID Numbers: 10-1260
First Posted: April 15, 2013    Key Record Dates
Last Update Posted: April 15, 2013
Last Verified: April 2013

Keywords provided by University of Colorado, Denver:
insulin resistance
ethnic disparities

Additional relevant MeSH terms:
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Hypoglycemic Agents
Physiological Effects of Drugs