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ClinicalTrials.gov Identifier: NCT01826747
Verified November 2012 by Universitaire Ziekenhuizen Leuven. Recruitment status was: Enrolling by invitation
The objective is to test the hypothesis that luteal phase support with vaginal progesterone leads to a higher clinical pregnancy rate (primary outcome) and live birth rate (secondary outcome) when compared to no luteal phase support in a program of intrauterine insemination (IUI) after controlled ovarian stimulation with gonadotrophins. Additionally, the length of the luteal phase will be recorded (secondary outcome) in order to detect luteal phase defects/insufficiencies in the absence of luteal phase suppletion as well as luteal phase prolongation in case of luteal phase support which may be a burden for the patients waiting for the outcome of the treatment.
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Ages Eligible for Study:
18 Years to 43 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with an indication for IUI:
mild male factor infertility
first IUI cycle ever
normal ovulatory cycles (26-32d)
presence of at least one patent tube on hysterosalpingography and/or laparoscopy
normal uterine cavity (ultrasound, hysterosalpingography, or laparoscopy)
Men: Total motile count ≥ 5 Million/ml after capacitation
Patients with contra-indication for pregnancy , infertility or progesterone use.