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Function and Modulation of Fibulin-1 Assembly in Nucleus of Corneal Fibroblasts

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ClinicalTrials.gov Identifier: NCT01808495
Recruitment Status : Unknown
Verified August 2015 by Tsan-Chi Chen, Far Eastern Memorial Hospital.
Recruitment status was:  Active, not recruiting
First Posted : March 11, 2013
Last Update Posted : August 13, 2015
Sponsor:
Information provided by (Responsible Party):
Tsan-Chi Chen, Far Eastern Memorial Hospital

Brief Summary:
The purpose of this study is to investigate the role of nuclear Fibulin-1 (FBLN1) in Human Corneal Fibroblasts under treatment of mitomycin C (MMC).

Condition or disease Intervention/treatment
Function of Mitomycin C in Cornea Drug: Mitomycin C

Study Type : Observational
Estimated Enrollment : 5 participants
Time Perspective: Prospective
Study Start Date : August 2012
Actual Primary Completion Date : July 2013
Estimated Study Completion Date : August 2015

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Modification of nuclear Fibulin-1 accumulation in suppressing gene expression [ Time Frame: 3 days post mitomycin C treatment ]


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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The original cell sources were collected from the donors with more than 20 years old following penetrating keratoplasty. After successfully amplified from the residual corneal rim following penetrating keratoplasty in the previous projects, human corneal fibroblasts (HCFs) were reserved in liquid nitrogen tank and were thawed for this study under in vitro cultivation and application.
Criteria

Inclusion Criteria:

  • The frozen storage cells in liquid nitrogen were amplified from the residual corneal rim of the donors with more than 20 years old following penetrating keratoplasty.

Exclusion Criteria:

  • The donors were younger than 20 years old.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01808495


Sponsors and Collaborators
Far Eastern Memorial Hospital
Investigators
Principal Investigator: Tsan-Chi Chen, PhD Far Eastern Memorial Hospital

Responsible Party: Tsan-Chi Chen, Department of Ophthalmology, Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier: NCT01808495     History of Changes
Other Study ID Numbers: FEMH-IRB-101002-F
NSC101-2320-B-418-002 ( Other Grant/Funding Number: NSC101-2320-B-418-002 )
First Posted: March 11, 2013    Key Record Dates
Last Update Posted: August 13, 2015
Last Verified: August 2015

Keywords provided by Tsan-Chi Chen, Far Eastern Memorial Hospital:
Human corneal fibroblasts
Fibulin-1
Nuclear accumulation

Additional relevant MeSH terms:
Mitomycins
Mitomycin
Antibiotics, Antineoplastic
Antineoplastic Agents
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors