Vitamin D Retrospective Study and Role With Disease
|Vitamin D Status Glucose Tolerance Blood Pressure Bone Mineral Density Hyperlipidemia||Other: Vitamin D|
|Study Design:||Observational Model: Other
Time Perspective: Retrospective
|Official Title:||Association of Vitamin D With Diabetes, Osteoporosis and Cardiovascular Risk|
- Vitamin D [ Time Frame: Day 1 ]Vitamin D level ng/dl
- IGF-1 [ Time Frame: Day 1 ]Insulin like growth factor
- IGF binding proteins [ Time Frame: Day 1 ]Insulin Growth Factor Binding protein levels
- PTH [ Time Frame: Day 1 ]Parathyroid Hormone levels
Biospecimen Retention: Samples With DNA
|Study Start Date:||November 2009|
|Estimated Study Completion Date:||December 2018|
|Estimated Primary Completion Date:||November 2018 (Final data collection date for primary outcome measure)|
Other: Vitamin D
N/A, frozen specimen study
The heightened prevalence of obesity in aging especially in postmenopausal women suggests that interventions to raise Vitamin D levels might be preventive of these diseases. Investigators have completed studies of the effects of weight loss and exercise interventions in approximately 400 older women and men over the last 15 years, many of whom are obese. Investigators have data on glucose tolerance, blood pressure and bone density in these studies and stored plasma in which investigators can analyze Vitamin D levels. Vitamin D may be an important risk factor for these metabolic diseases and the availability of these samples for Vitamin D analysis will allow investigators to perform a cross-sectional study to address relationships of Vitamin D levels to glucose intolerance and diabetes, hypertension/blood pressure status, bone mineral density, the degree of obesity, and physical activity status measured as maximal aerobic capacity and accelerometry in these older men and women.
The results of this study have the potential to impact clinical practice in the prevention and treatment of diabetes, hypertension, and osteopenia/osteoporosis. This would circumvent the current dilemma for prevention of these chronic diseases through treatment of obesity, as these data would provide immediate prospects for changing the recommended doses of Vitamin D beneficial for reducing risk for these diseases.
The purpose of this study is to 1) determine the prevalence of Vitamin D deficiency in obese, older men and postmenopausal women and 2) the association of Vitamin D levels to glucose tolerance, blood pressure, bone mineral density, and hyperlipidemia, as well as association with Vitamin D receptor gene polymorphisms affecting metabolic responses to Vitamin D.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01798030
|United States, Maryland|
|Baltimore, Maryland, United States, 21201|
|Principal Investigator:||Alice S Ryan, PhD||Baltimore VAMC|