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Does Cold Provocation Increase Brown Adipose Tissue Volume?

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ClinicalTrials.gov Identifier: NCT01797328
Recruitment Status : Completed
First Posted : February 22, 2013
Results First Posted : April 25, 2017
Last Update Posted : April 25, 2017
Sponsor:
Information provided by (Responsible Party):
Fredrik H Nystrom, University Hospital, Linkoeping

Brief Summary:
About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks. Basal metabolic rate and magnetic resonance (for determination of brown adipose tissue volume) imaging are performed before and after the study.

Condition or disease Intervention/treatment
Brown Adipose Tissue, Human Procedure: cold arm Procedure: warm arm

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 28 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Study of the Effects of Temperature on Amount of Brown Adipose Tissue in Humans
Study Start Date : February 2013
Primary Completion Date : May 2015
Study Completion Date : June 2015

Arm Intervention/treatment
Active Comparator: cold provocation
cold arm
Procedure: cold arm
1 hour/day of cold provocation of such an extent that it is unpleasant but does not cause shivering
Active Comparator: to avoid feeling cold
warm arm
Procedure: warm arm
To the best of ability avoid feeling cold during 6 weeks



Primary Outcome Measures :
  1. Brown Adipose Tissue, Absolute Volume [ Time Frame: Baseline and 6 week ]
    Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters)



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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: healthy subjects -

Exclusion Criteria: any significant disease, ot other conditions that interferes with magnetic resonance imaging


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01797328


Locations
Sweden
Faculty of Health Science, Linköping
Linköping, Sweden, 58185
Sponsors and Collaborators
University Hospital, Linkoeping

Responsible Party: Fredrik H Nystrom, Professor, MD, Head of internal medicine, University Hospital, Linkoeping
ClinicalTrials.gov Identifier: NCT01797328     History of Changes
Other Study ID Numbers: Nystrom_koldstudie
Dnr2013/41-32 ( Other Identifier: Linkoping review board, Sweden )
First Posted: February 22, 2013    Key Record Dates
Results First Posted: April 25, 2017
Last Update Posted: April 25, 2017
Last Verified: April 2017

Keywords provided by Fredrik H Nystrom, University Hospital, Linkoeping:
brown adipose tissue, human