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Does Cold Provocation Increase Brown Adipose Tissue Volume?

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01797328
First Posted: February 22, 2013
Last Update Posted: April 25, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Fredrik H Nystrom, University Hospital, Linkoeping
  Purpose
About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks. Basal metabolic rate and magnetic resonance (for determination of brown adipose tissue volume) imaging are performed before and after the study.

Condition Intervention
Brown Adipose Tissue, Human Procedure: cold arm Procedure: warm arm

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Study of the Effects of Temperature on Amount of Brown Adipose Tissue in Humans

Further study details as provided by Fredrik H Nystrom, University Hospital, Linkoeping:

Primary Outcome Measures:
  • Brown Adipose Tissue, Absolute Volume [ Time Frame: Baseline and 6 week ]
    Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters)


Enrollment: 28
Study Start Date: February 2013
Study Completion Date: June 2015
Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: cold provocation
cold arm
Procedure: cold arm
1 hour/day of cold provocation of such an extent that it is unpleasant but does not cause shivering
Active Comparator: to avoid feeling cold
warm arm
Procedure: warm arm
To the best of ability avoid feeling cold during 6 weeks

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria: healthy subjects -

Exclusion Criteria: any significant disease, ot other conditions that interferes with magnetic resonance imaging

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01797328


Locations
Sweden
Faculty of Health Science, Linköping
Linköping, Sweden, 58185
Sponsors and Collaborators
University Hospital, Linkoeping
  More Information

Responsible Party: Fredrik H Nystrom, Professor, MD, Head of internal medicine, University Hospital, Linkoeping
ClinicalTrials.gov Identifier: NCT01797328     History of Changes
Other Study ID Numbers: Nystrom_koldstudie
Dnr2013/41-32 ( Other Identifier: Linkoping review board, Sweden )
First Submitted: February 18, 2013
First Posted: February 22, 2013
Results First Submitted: October 26, 2016
Results First Posted: April 25, 2017
Last Update Posted: April 25, 2017
Last Verified: April 2017

Keywords provided by Fredrik H Nystrom, University Hospital, Linkoeping:
brown adipose tissue, human