The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation (RECOPD)
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|ClinicalTrials.gov Identifier: NCT01786928|
Recruitment Status : Completed
First Posted : February 8, 2013
Last Update Posted : February 8, 2013
|Condition or disease||Intervention/treatment||Phase|
|Chronic Obstructive Pulmonary Disease||Other: Resistance training||Not Applicable|
Acute exacerbations are common in patients with COPD and cause specific signs and symptoms, such as increased dyspnea, productive cough with altered sputum, and fever. With disease progression, exacerbations are frequent and have a negative impact on health related quality of life and pulmonary function as well as increase mortality. More severe exacerbations require hospitalization resulting in enormous health expenditures, severely reducing daily life activities and declining peripheral muscle strength that can be only partially reversed after 3 months. Despite many features have been pointed out as responsible for the decrease in muscle strength during hospitalization, physical inactivity seems the most important.
Resistance training is an interesting therapeutic option to prevent and/or reverse muscular dysfunction due to immobilised in healthy subjects and stable COPD patients because induces hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In addition, provokes lower dyspnea perception during effort compared with other exercise training. Despite these benefits for stable COPD, the impact of a resistance exercise program during hospitalization remains poorly known.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||34 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Impact of Resistance Training During Hospitalization in COPD Patients: a Randomized and Controlled Trial|
|Study Start Date :||April 2009|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||October 2010|
Experimental: resistance training
resistance training of the upper and lower limbs, two series of 80% of repetition maximum test
Other: Resistance training
Resistance training group received training program for upper (shoulder flexion and abduction and biceps) and lower limbs (knee extension and flexion and hip flexion). Daily exercise for every muscle was performed with free weights at 80% of an maximal repetition test and a 4 minutes rest was allowed between each step.
No Intervention: Control
Traditional Respiratory Therapy for bronchial hygiene
- The benefits of resistance training during exacerbation of COPD on peripheral muscle strength during hospitalization [ Time Frame: Will be evaluated on the second day of hospitalization, the day of hospital discharge (this time interval must be longer than five days) ]The metric used to evaluate the strength gain is given in kilogram (absolute value) and percentage relative to that obtained on the second hospital day
- The benefits of resistance training during exacerbation of COPD on physical activity in daily life [ Time Frame: Will be evaluated in the third and fifth day of hospitalization and thirty days after discharge ]The metric used to evaluate the changes will be given in minutes and percentage of total time
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01786928
|University Hospital of sao paulo|
|São Paulo, Brazil, 05508-000|
|Study Chair:||Rodrigo C Borges, specialist||school of Medicine university of sao paulo|