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The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation (RECOPD)

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ClinicalTrials.gov Identifier: NCT01786928
Recruitment Status : Completed
First Posted : February 8, 2013
Last Update Posted : February 8, 2013
Sponsor:
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Information provided by (Responsible Party):
Celso Ricardo Fernandes de Carvalho, University of Sao Paulo

Brief Summary:
The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

Condition or disease Intervention/treatment Phase
Chronic Obstructive Pulmonary Disease Other: Resistance training Not Applicable

Detailed Description:

Acute exacerbations are common in patients with COPD and cause specific signs and symptoms, such as increased dyspnea, productive cough with altered sputum, and fever. With disease progression, exacerbations are frequent and have a negative impact on health related quality of life and pulmonary function as well as increase mortality. More severe exacerbations require hospitalization resulting in enormous health expenditures, severely reducing daily life activities and declining peripheral muscle strength that can be only partially reversed after 3 months. Despite many features have been pointed out as responsible for the decrease in muscle strength during hospitalization, physical inactivity seems the most important.

Resistance training is an interesting therapeutic option to prevent and/or reverse muscular dysfunction due to immobilised in healthy subjects and stable COPD patients because induces hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In addition, provokes lower dyspnea perception during effort compared with other exercise training. Despite these benefits for stable COPD, the impact of a resistance exercise program during hospitalization remains poorly known.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 34 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Impact of Resistance Training During Hospitalization in COPD Patients: a Randomized and Controlled Trial
Study Start Date : April 2009
Actual Primary Completion Date : December 2009
Actual Study Completion Date : October 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases

Arm Intervention/treatment
Experimental: resistance training
resistance training of the upper and lower limbs, two series of 80% of repetition maximum test
Other: Resistance training
Resistance training group received training program for upper (shoulder flexion and abduction and biceps) and lower limbs (knee extension and flexion and hip flexion). Daily exercise for every muscle was performed with free weights at 80% of an maximal repetition test and a 4 minutes rest was allowed between each step.

No Intervention: Control
Traditional Respiratory Therapy for bronchial hygiene



Primary Outcome Measures :
  1. The benefits of resistance training during exacerbation of COPD on peripheral muscle strength during hospitalization [ Time Frame: Will be evaluated on the second day of hospitalization, the day of hospital discharge (this time interval must be longer than five days) ]
    The metric used to evaluate the strength gain is given in kilogram (absolute value) and percentage relative to that obtained on the second hospital day


Secondary Outcome Measures :
  1. The benefits of resistance training during exacerbation of COPD on physical activity in daily life [ Time Frame: Will be evaluated in the third and fifth day of hospitalization and thirty days after discharge ]
    The metric used to evaluate the changes will be given in minutes and percentage of total time



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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patients hospitalized for exacerbation of COPD

Exclusion Criteria:

  • patients presenting change in mental status (confusion, lethargy or coma)
  • persistence or worsening in hypoxemia (PaO2<40mmHg) and/or respiratory acidosis (pH<7.25) despite oxygen supplementation or use of non-invasive ventilation
  • hemodynamic instability requiring vasoactive drugs
  • patients transferred to ICU
  • hospitalization lower than 5 days
  • diseases that prevented the exercises

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01786928


Locations
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Brazil
University Hospital of sao paulo
São Paulo, Brazil, 05508-000
Sponsors and Collaborators
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo
Investigators
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Study Chair: Rodrigo C Borges, specialist school of Medicine university of sao paulo
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Celso Ricardo Fernandes de Carvalho, PhD in physiology, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT01786928    
Other Study ID Numbers: PTR-001-RCB
First Posted: February 8, 2013    Key Record Dates
Last Update Posted: February 8, 2013
Last Verified: February 2013
Keywords provided by Celso Ricardo Fernandes de Carvalho, University of Sao Paulo:
chronic obstructive pulmonary disease
exacerbation
resistance training
muscle force
Additional relevant MeSH terms:
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Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases