Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia
|ClinicalTrials.gov Identifier: NCT01783093|
Recruitment Status : Completed
First Posted : February 4, 2013
Last Update Posted : February 4, 2013
The purpose of this study is to evaluate patients with pulmonary hypertension and sickle cell disease who have had multiple echocardiograms. Previous studies have shown that an elevated tricuspid jet (TR) regurgitant velocity on echo in this population is a predictor of mortality. This initial data only examined an isolated TR jet velocity. It was presumed that the mortality was related to pulmonary hypertension.
It is the aim of this study to retrospectively evaluate patients who have had multiple echocardiograms and to determine if patients who had either a normalization of their TR jet velocity on a subsequent echo or had no evidence of pulmonary hypertension on right heart catheterization had a similar mortality rate to those with persistently elevated TR jet velocity.
|Condition or disease||Intervention/treatment|
|Sickle Cell Anemia Pulmonary Hypertension||Other: Data Collection|
|Study Type :||Observational|
|Actual Enrollment :||209 participants|
|Official Title:||An Evaluation of Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Patients With Sickle Cell Anemia: A Retrospective Data Review|
|Study Start Date :||December 2009|
|Actual Primary Completion Date :||January 2013|
|Actual Study Completion Date :||January 2013|
|Sickle cell and pulmonary hypertension||
Other: Data Collection
Collection of data from existing medical records
- A retrospective review on patients who have had multiple echocardiograms to determine if patients with a normalization of TR Jet Velocity have changes in risk of death compared with those who do not have normalization of TR Jet Velocity. [ Time Frame: Up to 20 years ]Any subject's who meet criteria and have multiple echocardiograms may be included.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01783093
|United States, Ohio|
|The Ohio State University Medical Center|
|Columbus, Ohio, United States, 43221|
|Principal Investigator:||Namita Sood, M.D.||Ohio State University|