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Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01781364
First Posted: February 1, 2013
Last Update Posted: December 16, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Prof. Dr. Brigitte Rockstroh, University of Konstanz
  Purpose
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on course and rehabilitation in early onset schizophrenia

Condition Intervention
Psychosis Behavioral: Brain Fitness Training, Posit Science SF

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia

Resource links provided by NLM:


Further study details as provided by Prof. Dr. Brigitte Rockstroh, University of Konstanz:

Primary Outcome Measures:
  • change from baseline at post-training and at 3-months and at 7-months follow-up in each of the following outcome measures: neuropsychological test performance (MCCCB), GAF, PANSS, MEG event-related potentials (M50), alpha activity [ Time Frame: baseline, post-training (training duration 4 weeks), 3-month follow-up, 7-month follow-up ]

Secondary Outcome Measures:
  • change from baseline in GAF score at 3-months and 7-moths follow-up [ Time Frame: baseline, 3-months follow-up, 7-months follow-up ]

Enrollment: 20
Study Start Date: January 2012
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitive Training
Brain Fitness Training, Posit Science SF
Behavioral: Brain Fitness Training, Posit Science SF
Computer aided cognitive training based on principles of neuroplasticity

Detailed Description:
Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. We examine the beneficial effect of computer-aided training program on course and rehabilitation of young psychotic patients with early onset psychosis. In addition we develop predictors for the course of disorder from neuroimaging data.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 37 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Early Onset Psychosis

Exclusion Criteria:

  • Chronicity
  • Insufficient German skills
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01781364


Locations
Germany
University Konstanz
Konstanz, Baden Wuerttemberg, Germany, 78464
Sponsors and Collaborators
University of Konstanz
Investigators
Study Director: Brigitte S Rockstroh, Prof. Dr. University of Konstanz
  More Information

Responsible Party: Prof. Dr. Brigitte Rockstroh, Prof. Dr., University of Konstanz
ClinicalTrials.gov Identifier: NCT01781364     History of Changes
Other Study ID Numbers: FP16963311
First Submitted: January 22, 2013
First Posted: February 1, 2013
Last Update Posted: December 16, 2014
Last Verified: December 2014

Keywords provided by Prof. Dr. Brigitte Rockstroh, University of Konstanz:
Brain Oscillations
Cognitive Performance

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders