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Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers

This study has been completed.
Information provided by (Responsible Party):
Bo Ahren, Lund University Identifier:
First received: January 27, 2013
Last updated: September 29, 2014
Last verified: September 2014
To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers

Condition Intervention
Healthy Volunteers Recruited From the General Population
Other: Mixed meal

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin

Further study details as provided by Bo Ahren, Lund University:

Primary Outcome Measures:
  • Area under the curve for insulin [ Time Frame: 300 min ]

Secondary Outcome Measures:
  • Area under the curve for glucose-dependent insuinotropic polypeptide [ Time Frame: 300 min ]
  • Area under the curve for glucagon-like peptide-1 [ Time Frame: 300 min ]

Other Outcome Measures:
  • Area under the curve for glucagon [ Time Frame: 300 min ]

Enrollment: 24
Study Start Date: June 2013
Study Completion Date: June 2014
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Healthy volunteers are ingesting a mixed meal either rapidly or slowly
Other: Mixed meal
Ingestion of mixed meal

Detailed Description:
A mixed meal (524 kcal) is ingested rapidly (within 5 min) or slowly (10-15 min) and changes in insulin, glucagon, GIP and GLP-1 levels are followed for subsequent 300 min

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy subjects

Exclusion Criteria:

  • Diabetes Liver disease Kidney disease Thyroid disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01779622

Department of Clinical Sciences, Lund University
Lund, Sweden, 22184
Sponsors and Collaborators
Lund University
  More Information

Additional Information:
Responsible Party: Bo Ahren, Professor, Lund University Identifier: NCT01779622     History of Changes
Other Study ID Numbers: 17
2013-000449-38 ( EudraCT Number )
Study First Received: January 27, 2013
Last Updated: September 29, 2014

Keywords provided by Bo Ahren, Lund University:
mixed meal¨

Additional relevant MeSH terms:
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on May 25, 2017