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Ischemic Preconditioning in Endurance Athletes

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ClinicalTrials.gov Identifier: NCT01774461
Recruitment Status : Completed
First Posted : January 24, 2013
Last Update Posted : March 19, 2014
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center

Brief Summary:
The aim of this study is to investigate the effect of remote ischemic preconditioning on biochemical and functional indices of cardiac function induced by a 30 km run in healthy trained long distance runners.

Condition or disease Intervention/treatment Phase
Exercise Other: Remote ischemic preconditioning Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 29 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: Influence of Remote Ischemic Preconditioning on Cardiac Function After Endurance Exercise
Study Start Date : March 2013
Actual Primary Completion Date : September 2013
Actual Study Completion Date : September 2013

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
No Intervention: Sham RIC
Control treatment (sham RIC) will consist of four 5-minute simulated inflations of a blood pressure cuff placed on the upper arm. The inflations will be separated by 5-minute periods when the blood pressure cuff will be deflated.
Active Comparator: Remote ischemic conditioning
Blood pressure cuff placed on upper arm and inflated to 200mmHg for 5 minutes then deflated for 5 minutes - this cycle is repeated a total of 4 times.
Other: Remote ischemic preconditioning
Blood pressure cuff placed on upper arm and inflated to 200mmHg for 5 minutes then deflated for 5 minutes - this cycle is repeated a total of 4 times.




Primary Outcome Measures :
  1. Serum concentrations of cardiac troponins [ Time Frame: 6 hours, 2 hourly time intervals ]

Secondary Outcome Measures :
  1. Indices of cardiac function measured by echocardiography [ Time Frame: 2 hours post-exercise ]


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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Informed consent
  • Healthy
  • Age between 18 and 65 years
  • Endurance-trained (two or more training sessions per week)

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01774461


Locations
Netherlands
Maastricht University Medical Center
Maastricht, Netherlands
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Marja van Dieijen-Visser, PhD Department of Clinical Chemistry, MUMC, Maastricht, the Netherlands

Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01774461     History of Changes
Other Study ID Numbers: METC12-2-038
First Posted: January 24, 2013    Key Record Dates
Last Update Posted: March 19, 2014
Last Verified: March 2014