Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function
|ClinicalTrials.gov Identifier: NCT01718405|
Recruitment Status : Unknown
Verified October 2012 by Hillel Yaffe Medical Center.
Recruitment status was: Not yet recruiting
First Posted : October 31, 2012
Last Update Posted : October 31, 2012
|Condition or disease||Intervention/treatment||Phase|
|Executive Function||Other: Cognitive function after exercise test Genetic: Blood sample analysis||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||150 participants|
|Intervention Model:||Single Group Assignment|
|Primary Purpose:||Basic Science|
|Study Start Date :||November 2012|
|Estimated Primary Completion Date :||November 2015|
|Estimated Study Completion Date :||November 2017|
Experimental: Exercise Group
Each individual subject will give a blood sample for genetic analysis and undertake an exercise session and a rest session as a control. Cognitive function will be tested before and after each session.
Other: Cognitive function after exercise test
The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order. Before and after each session, the subject will take computerized cognitive tests.Genetic: Blood sample analysis
In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.
- Cognitive Functioning After Exercise [ Time Frame: Five minutes ]Computerized battery of tests evaluating cognitive functioning
- Genetic Variation Associated with Different Cognitive Functioning [ Time Frame: Two years ]Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism. A mutation will be discriminated by digestion with specific restriction endonucleases.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01718405
|Contact: Sharon Tsuk, PhDfirstname.lastname@example.org|
|Wingate Institute||Not yet recruiting|
|Principal Investigator: Raffael Carasso, MD|
|Sub-Investigator: Sharon Tsuk, PhD|