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Carbohydrate Use During and Following Exercise (CHO-use)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2012 by Maastricht University Medical Center.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01709617
First Posted: October 18, 2012
Last Update Posted: October 18, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Maastricht University Medical Center
  Purpose
Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.

Condition Intervention
Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise Dietary Supplement: Carbohydrate ingestion

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Official Title: Sucrose as a Preferred Carbohydrate in Sports Nutrition

Resource links provided by NLM:


Further study details as provided by Maastricht University Medical Center:

Primary Outcome Measures:
  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 0 min during trials 1-3 ]
    Carbohydrate oxidation as measured by breath samples

  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 0 min during trials 1-3 ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3

  • Glycogen utilization (Part B) [ Time Frame: immediately post exercise (~90min), during trials 4-6 ]

    Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

    Part B; trials 4-6.


  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 30 min during trials 1-3 ]
    Carbohydrate oxidation as measured by breath samples

  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 60 min during trials 1-3 ]
    Carbohydrate oxidation as measured by breath samples

  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 90 min during trials 1-3 ]
    Carbohydrate oxidation as measured by breath samples

  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 120 min during trials 1-3 ]
    Carbohydrate oxidation as measured by breath samples

  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 150 min during trials 1-3 ]
    Carbohydrate oxidation as measured by breath samples

  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 180 min during trials 1-3 ]
    Carbohydrate oxidation as measured by breath samples

  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 30 min during trials 1-3 ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3

  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 60 min during trials 1-3 ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3

  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 90 min during trials 1-3 ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3

  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 120 min during trials 1-3 ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3

  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 150 min during trials 1-3 ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3

  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 180 min during trials 1-3 ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3

  • Glycogen utilization (Part B) [ Time Frame: 3 h post exercise during trials 4-6 ]

    Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

    Part B; trials 4-6.


  • Glycogen utilization (Part B) [ Time Frame: 6 h post exercise during trials 4-6 ]

    Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

    Part B; trials 4-6.



Secondary Outcome Measures:
  • Indirect calorimetry (Part A) [ Time Frame: every 30 min up to 180 min during trials 1-3 ]
    Measurements of VO2, VCO2 and RER through indirect calorimetry measured every 30 minutes during trials 1-3

  • Plasma glucose [ Time Frame: every 30 min up to 180 min during trials 1-6 ]
    Plasma glucose measurements

  • Plasma insulin [ Time Frame: every 30 minutes up to 180 min during trials 1-6 ]
    plasma insulin measurements


Estimated Enrollment: 17
Study Start Date: November 2012
Estimated Study Completion Date: January 2014
Estimated Primary Completion Date: September 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Glucose-glucose
Glucose ingestion
Dietary Supplement: Carbohydrate ingestion
Various types of carbohydrate ingested during and following exercise
Active Comparator: Glucose-Fructose
glucose-fructose ingestion
Dietary Supplement: Carbohydrate ingestion
Various types of carbohydrate ingested during and following exercise
Active Comparator: disaccharide
Disaccharide ingestion
Dietary Supplement: Carbohydrate ingestion
Various types of carbohydrate ingested during and following exercise

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • Male
  • 18 - 40 years of age
  • Endurance trained cyclist/triathlete
  • VO2 max ≥ 50 ml/kg/min
  • BMI < 25 kg/m2

Exclusion Criteria:

  • Use of medication
  • Smoking
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01709617


Contacts
Contact: Naomi Cermak, Ph.D. 31433881393 naomi.cermak@maastrichtuniversity.nl

Locations
Netherlands
Maastricht University Not yet recruiting
Maastricht, Limburg, Netherlands, 6200MD
Contact       ncermak@gmail.com   
Sponsors and Collaborators
Maastricht University Medical Center
Investigators
Principal Investigator: Luc van Loon, Ph.D. Maastricht University
  More Information

Responsible Party: Maastricht University Medical Center
ClinicalTrials.gov Identifier: NCT01709617     History of Changes
Other Study ID Numbers: 12-3-048
First Submitted: October 11, 2012
First Posted: October 18, 2012
Last Update Posted: October 18, 2012
Last Verified: October 2012

Keywords provided by Maastricht University Medical Center:
carbohydrate, glycogen, glucose