Lean Seafood Intake and Postprandial Metabolism (LeSIP)
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ClinicalTrials.gov Identifier: NCT01708681 |
Recruitment Status :
Completed
First Posted : October 17, 2012
Last Update Posted : October 6, 2015
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Despite numerous studies of meal components in humans, little is still known about how different meals influence on metabolism. The purpose of this study is to a gain knowledge of how a balanced test meal with either lean seafood (example:cod) or meat as the main protein source will:
- affect the postprandial metabolism acutely (test-meal at beginning of the study)
- affect the postprandial metabolism after 4 weeks controlled intervention (test meal at end of intervention period)
- affect gut microbiota composition
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Hyperlipidemias Nutritional and Metabolic Diseases Nutrition Disorders Metabolic Diseases Glucose Metabolism Disorders | Dietary Supplement: Lean seafood Dietary Supplement: Meat, egg, milk | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 27 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Investigator) |
Primary Purpose: | Basic Science |
Official Title: | Ability of a Lean Seafood Diet to Modulate Postprandial Metabolism in Human-beings - a Controlled Intervention Study With Cross-over Design |
Study Start Date : | October 2012 |
Actual Primary Completion Date : | May 2013 |
Actual Study Completion Date : | September 2015 |

Arm | Intervention/treatment |
---|---|
Experimental: Lean seafood
Cross-over design, half of the subject will receive lean seafood in study period I and the other half in study period II
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Dietary Supplement: Lean seafood Dietary Supplement: Meat, egg, milk |
Active Comparator: Meat, egg, milk
Cross-over design, half of the subject will receive meat, egg, milk in study period I and the other half in study period II
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Dietary Supplement: Lean seafood Dietary Supplement: Meat, egg, milk |
- Postprandial lipid measurement [ Time Frame: Change from baseline at 4 weeks ]
- Postprandial glucose measurement [ Time Frame: Change from baseline at 4 weeks ]
- Postprandial metabolomic measurement [ Time Frame: Change from baseline at 4 weeks ]
- Gut microbiota composition [ Time Frame: Change from baseline at 4 weeks ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- 18-65 years of age
- Caucasian
Exclusion Criteria:
- Smoking
- Diabetes
- Hysterectomy
- Abnormal bleeding last 6 months
- Use of medication that affects lipid and glucose metabolism
- Large (>10%) alteration in body-weight the last 6 months
- Chronic, metabolic or acute disease or major surgery within last 3 months
- Dietary incompatibility with calcium supplementation and/ or seafood consumption (allergy, intolerance, dislike)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01708681
Norway | |
National Institute of Nutrition and Seafood Research | |
Bergen, Norway, 5005 |
Principal Investigator: | Bjørn Liaset, Dr | NIFES |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | National Institute of Nutrition and Seafood Research, Norway |
ClinicalTrials.gov Identifier: | NCT01708681 |
Other Study ID Numbers: |
NIFES-001 2012/1084/REK vest ( Other Grant/Funding Number: NRC-200515/I30 ) |
First Posted: | October 17, 2012 Key Record Dates |
Last Update Posted: | October 6, 2015 |
Last Verified: | October 2015 |
Seafood Meat Egg Milk Postprandial lipid metabolism |
Postprandial glucose metabolism Triglycerides Cholesterol Postprandial incretins Postprandial hormones |
Hyperlipidemias Metabolic Diseases Glucose Metabolism Disorders Nutrition Disorders |
Disease Pathologic Processes Dyslipidemias Lipid Metabolism Disorders |