Sweat Evaporimeter Measurement
|ClinicalTrials.gov Identifier: NCT01708655|
Recruitment Status : Completed
First Posted : October 17, 2012
Last Update Posted : December 3, 2014
The investigators hypothesize that measurement of beta adrenergic induced sweat rate using an evaporimeter can accurately and reliably determine different levels of CFTR dysfunction within a spectrum of patients expressing various degrees of cystic fibrosis disease.
The investigators overall goal is to determine whether the evaporimeter technique of measuring beta-adrenergic induced sweat rate is capable of accurately and reliably identifying different levels of CFTR dysfunction, as a prerequisite before advancing this technique as biomarker assay into clinical trials.
|Condition or disease||Intervention/treatment||Phase|
|Cystic Fibrosis||Other: Sweat Evaporimeter measurement||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||16 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Evaluation of the Accuracy and Reliability of B-Adrenergic Sweat Secretion Using an Evaporimeter to Assess CFTR Function in Cystic Fibrosis|
|Study Start Date :||December 2011|
|Actual Primary Completion Date :||August 2014|
|Actual Study Completion Date :||December 2014|
Sweat Evaporimeter measurement
Other: Sweat Evaporimeter measurement
The procedure would take about 45 minutes.
- Measurement of beta-adrenergic induced sweat rate using an evaporimeter can accurately and reliably determine different levels of CFTR dysfunction within a spectrum of patients expressing various degrees of CF disease. [ Time Frame: Up to 2 hours ]The response patterns will be interpreted and classified by the study PI, as consistent or inconsistent to the published standards. The obtained measurements will be compared to the results obtained from a recently finished validation trial. According to the result of this trial the ranges were as followed: cholinergic response for all subjects 60±20 Evaporimeter units, beta-adrenergic response: Healthy control 51 ± 20 heterozygote -22 ±20, CF -1.4 ±2.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01708655
|United States, Colorado|
|Children's Hospital Colorado|
|Aurora, Colorado, United States, 80045|
|Principal Investigator:||Frank J Accurso, MD||Children's Hospital Colorado|