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Effects of Legumes on Glucose Regulation

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01706042
First Posted: October 15, 2012
Last Update Posted: October 15, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Anti-Diabetic Food Centre
Information provided by (Responsible Party):
Anne Nilsson, Lund University
  Purpose
Dietary prevention strategies are increasingly recognized as essential to combat the current epidemic of obesity and related metabolic disorders. The purpose of the present study was to evaluate the potential effects of legumes in relation to cardiometabolic risk markers and appetite regulating hormones.

Condition Intervention
Dietary Prevention Other: legume meal Other: white bread

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Over-night Metabolic Effects of Legumes

Further study details as provided by Anne Nilsson, Lund University:

Primary Outcome Measures:
  • blood glucose [ Time Frame: 11 hours ]
    A portion of legumes or bread was consumed as a late evening meal, blood glucose was measured the next morning at breakfast.


Secondary Outcome Measures:
  • satiety [ Time Frame: 11 hours ]
    legumes or bread was consumed as a late evening meal, satiety hormones (PYY, oxyntomodulin)and appetite sensations were determined at a following breakfast.


Other Outcome Measures:
  • inflammatory markers [ Time Frame: 11 hours ]
    legumes or bread was consumed as a late evening meal, inflammatory markers (IL-6, IL-8)was determined at a following breakfast.


Enrollment: 16
Study Start Date: February 2010
Study Completion Date: August 2011
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: white bread
White bread (based on 35 g available carbohydrates)
Other: white bread
Active Comparator: Legume meal
Legumes are consumed as a late evening meal(based on 35 g available carbohydrates)
Other: legume meal

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects between 20-35 years
  • With normal BMI and
  • No known metabolic- or gastro intestinal disease

Exclusion Criteria:

  • BMI > 25,
  • Known metabolic disorder or
  • Gastrointestinal problems or disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01706042


Locations
Sweden
Applied Nutrition and Food Chemistry, Lund University
Lund, Sweden, SE-22100
Sponsors and Collaborators
Lund University
Anti-Diabetic Food Centre