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Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma (acute asthma)

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ClinicalTrials.gov Identifier: NCT01690793
Recruitment Status : Completed
First Posted : September 24, 2012
Last Update Posted : May 28, 2015
Sponsor:
Information provided by (Responsible Party):
Richard Lockey, University of South Florida

Brief Summary:
The investigators hypothesize that there is a statistically significant decrease of Natriuretic Hormone Peptides (NHPs) in subjects with asthma exacerbation compared to levels following treatment of an exacerbation of asthma.

Condition or disease
ASTHMA

Detailed Description:

Overall Study Design

  1. Measurement of Natriuretic Hormone Peptides in individuals suffering from exacerbation of asthma.
  2. Measurement of Natriuretic Hormone Peptides 5-7 days after initiation of treatment of exacerbation of asthma.
  3. Measurement of Natriuretic Hormone Peptides 10-14 days after initiation of treatment of exacerbation of asthma.

3 comparisons of Natriuretic Hormone Peptides levels will be made:

  1. Exacerbation compared to 5-7 days after initiation of treatment
  2. Exacerbation compared to 10-14 days after initiation of treatment
  3. 5-7 days after initiation of treatment compared to 10-14 days after initiation of treatment.

Samples of blood will be secured in the Division of Allergy/Immunology at the University of South Florida, Joy McCann Culverhouse Airways Disease Center. All samples will be appropriately coded to maintain confidentiality. Blood specimens will be held at minus 20 degrees Celsius.


Study Type : Observational
Actual Enrollment : 30 participants
Official Title: Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma
Study Start Date : February 2009
Actual Primary Completion Date : December 2010
Actual Study Completion Date : February 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma Hormones
U.S. FDA Resources




Primary Outcome Measures :
  1. The measurement of NHPs after treatment of an exacerbation of asthma [ Time Frame: 14 days ]

Biospecimen Retention:   Samples With DNA
Samples of blood will be secured in the Division of Allergy/Immunology at the University of South Florida, Joy McCann Culverhouse Airways Disease Center. All samples will be appropriately coded to maintain confidentiality. Blood specimens will be held at minus 20 degrees Celsius. GENETICS SAMPLES ARE OPTIONAL


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

The Asthma Control Test score of less than 18.

Asthma control test consists of five questions, scored 1-5 each.

Criteria

Inclusion Criteria:

  • Both genders, age 18-85.
  • Females who are pregnant or lactating are not eligible.
  • Read and comprehend English.
  • Ability to give informed consent.
  • Seen in the outpatient setting at one of the clinic.
  • The subject must have a history of physician diagnosed asthma for at least 1 year and must have an exacerbation of asthma for entry into the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01690793


Locations
United States, Florida
Usf Asthma Allergy and Immunology Cru
Tampa, Florida, United States, 33613
Sponsors and Collaborators
University of South Florida

Responsible Party: Richard Lockey, prinicpal investigator, University of South Florida
ClinicalTrials.gov Identifier: NCT01690793     History of Changes
Other Study ID Numbers: acute asthma
First Posted: September 24, 2012    Key Record Dates
Last Update Posted: May 28, 2015
Last Verified: May 2015

Keywords provided by Richard Lockey, University of South Florida:
ASTHMA
ACUTE EXACERBATION OF ASTHMA

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases
Hormones
Natriuretic Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs