Effects of Spironolactone on Cardio- and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients
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ClinicalTrials.gov Identifier: NCT01687699
Recruitment Status :
First Posted : September 19, 2012
Last Update Posted : September 19, 2012
Dialysis Outcomes Heart Failure Aldactone Study Group
Information provided by (Responsible Party):
Yoshihiro Matsumoto, Dialysis Outcomes Heart Failure Aldactone Study Group
Aldosterone receptor blockers reduce cardiac-related morbidity and mortality. Recently, we demonstrated that long-term low-dose spironolactone is clinically safe in many hemodialysis (HD) patients. In the present study, we assess whether low-dose spironolactone treatment reduces the high incidence of cardio- and cerebrovascular (CCV) morbidity and mortality in HD patients. The investigators' hypothesis is that aldosterone receptor blockade by spironolactone reduces the risk of both CCV morbidity and death among HD patients.
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Ages Eligible for Study:
30 Years and older (Adult, Senior)
Sexes Eligible for Study:
Hemodialysis patients undergoing 4-hour-long HD thrice a week for at least 2 years
With an average serum potassium level (immediately before dialysis on the first day of the week) of <6.5 mEq/l over the previous 2 months