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Developmental Trajectory of Brain Structural Connectivity and Cognitive Function From Childhood to Adulthood

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2012 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
National Health Research Institutes, Taiwan
Information provided by (Responsible Party):
National Taiwan University Hospital Identifier:
First received: August 30, 2012
Last updated: August 31, 2012
Last verified: August 2012

Magnetic resonance imaging (MRI) is a premier modality to investigate structures and functions of human brain. In studies of children and adolescents, noninvasiveness of MRI makes it especially applicable. Developmental trajectory of gray matter volume and cortical thickness has been well studied in western countries. However, significant variability of brain structure has been reported between Chinese and Caucasian, and the variation may also exist in developmental trajectory of the brain. However, the maturation processes of neural fiber tracts in white matter are less understood. Diffusion tensor imaging (DTI), which has been frequently used to investigate the integrity of fibertracts in the literature, is limited in dealing with crossing fibers. Diffusion spectrum imaging (DSI) is a newly developed technique to improve the resolution of crossing fibers, and it is more suitable for detailed tractography assessment. In addition to establishing the template of brain structure (T1 and T2) and structural connectivity of our child, adolescent, and young adult population, the study has the following three aims.

  1. To describe gender effect and developmental change of brain volume of different cortical and subcortical regions, thickness of cortex brain, and structural connectivity (e.g., frono-striatal, fronto-pareital, fronto-temporal and fronto-cerebeller tracts and superior longitudinal fasciculus II) across childhood through adolescent to adulthood;
  2. To examine the gender effects and developmental change of attention, executive function and visual memory from childhood to adulthood and whether gender moderates these developmental changes; and
  3. To correlate the structural connectivity and brain size and neuropsychological function within the same subjects.

Brain Structural Connectivity Cognitive Function

Study Type: Observational
Official Title: Developmental Trajectory of Brain Structural Connectivity and Cognitive Function From Childhood to Adulthood

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 140
Study Start Date: January 2012
Estimated Study Completion Date: December 2014
Child and adolescent population

Detailed Description:

The investigators plan to recruit 140 healthy volunteers (70 males and 70 females), ages 8-21 without current and past history of any psychiatric disorder and autistic symptoms. All the participants will receive psychiatric interviews (K-SADS-E/SADS) and complete the Chinese AQ or SRS to screen for any psychiatric disorder or autistic symptoms. They will receive the WAIS-III or WISC-III (depending on their age) first to ensure their full-scale IQ greater than 80, followed by the CPT and CANTAB for a wide range assessments of attention, executive functions, and memory. The MRI assessments (T1 and T2 imaging, DSI, and resting-state fMRI) will be subsequently arranged within 2 weeks after psychiatric/neuropsychological assessments.

The investigators anticipate that this study (1) will establish the first template of brain anatomy and structural connectivity of children and adolescents in our population, (2) will be the first report on the developmental trajectory of brain of Chinese in both brain gross anatomy and tractography; (3) will provide evidence about how these development in brain structures associated with maturation in cognitive functions.


Ages Eligible for Study:   8 Years to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The sample consists of 140 healthy volunteers (70 males and 70 females). The ranges of age are 8-21 (around 5 males and 5 females in each age group). They will be recruited from schools and colleges.

Inclusion Criteria:

  • Ages 8-21 without current and past history of any psychiatric disorder and autistic symptoms.

Exclusion Criteria:

  • Current symptoms or lifetime history of DSM-IV-TR diagnosis of attention-deficit/hyperactivity disorder, pervasive developmental disorder, schizophrenia, schizoaffective disorder, delusional disorder, other psychotic disorder, organic psychosis, bipolar disorder, depression, severe anxiety disorders or substance use.
  • With neurodegenerative disorder, epilepsy, involuntary movement disorder, congenital metabolic disorder, brain tumor, history of severe head trauma, and history of craniotomy.
  • With major systemic disease.
  • Full-scale IQ < 80.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01677793

Contact: Susan Shur-Fen Gau, MD, PhD 886-2-23123456 ext 66802

National Taiwan Univeristy Hospital Recruiting
Taipei, Taiwan
Contact: Susan Shur-Fen Gau, MD, PhD    886-2-23123456 ext 66802   
Sponsors and Collaborators
National Taiwan University Hospital
National Health Research Institutes, Taiwan
Principal Investigator: Susan Shur-Fen Gau, MD, PhD National Taiwan University Hospital & College of Medicine
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: National Taiwan University Hospital, Susan Shur-Fen Gau Identifier: NCT01677793     History of Changes
Other Study ID Numbers: 201105115RC
Study First Received: August 30, 2012
Last Updated: August 31, 2012 processed this record on September 25, 2017