Comparison of 18-F Sodium Fluoride Uptake in Culprit Plaques Between Acute Coronary Syndrome and Stable Angina
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ClinicalTrials.gov Identifier: NCT01665248 |
Recruitment Status :
Terminated
First Posted : August 15, 2012
Last Update Posted : July 28, 2014
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Coronary Artery Diseases | Other: 18-F Sodium Fluoride Uptake in Positron emission tomography | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 20 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Diagnostic |
Official Title: | Comparison of 18-F Sodium Fluoride Uptake in Culprit Plaques Between Acute Coronary Syndrome and Stable Angina |
Study Start Date : | August 2012 |
Actual Primary Completion Date : | May 2013 |
Actual Study Completion Date : | May 2013 |
Arm | Intervention/treatment |
---|---|
stable angina pectoris or acute coronary syndrome |
Other: 18-F Sodium Fluoride Uptake in Positron emission tomography |
- Standardized 18F-NaF uptake value within the culprit plaque [ Time Frame: At the time of diagnosis ]
- The relationship between 18F-NaF uptake value and calcium scores by Multidetector Computed Tomography [ Time Frame: at the time of diagnosis ]
- The relationship between 18F-NaF uptake value and plaque types by Multidetector Computed Tomography [ Time Frame: at the time of diagnosis ]
- The relationship between 18F-NaF uptake value and biomarkers [ Time Frame: at the time of diagnosis ]hs-CRP, Troponin-I
- The relationship between 18F-NaF uptake value and invasive imagings [ Time Frame: at the time of diagnosis ]Intravascular ultrasound, Optical coherence tomography

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Ages Eligible for Study: | 21 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age more than 20
- Acute coronary syndrome or stable angina
Exclusion Criteria:
- Contraindications to the use of heparin, aspirin, clopidogrel, stainless metal, contrast media
- Acute ST segment elevation myocardial infarction within 12hours, heart failure, cardiac shock
- Any serious medical comorbidity such that the subject's life expectancy is less than 24 months
- Ejection fraction less than 30
- Serum creatinine level of 1.5mg/dl and over
- Vasculitis
- Unwillingness or inability to cooperate or to give informed consent

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01665248
Korea, Republic of | |
Asan Medical Center | |
Seoul, Korea, Republic of |
Principal Investigator: | Cheol Whan Lee, MD, PhD | Asan Medical Center |
Responsible Party: | CHEOL WHAN LEE, MD, PhD., MD, PhD, CardioVascular Research Foundation, Korea |
ClinicalTrials.gov Identifier: | NCT01665248 |
Other Study ID Numbers: |
AMCCV2012-03 |
First Posted: | August 15, 2012 Key Record Dates |
Last Update Posted: | July 28, 2014 |
Last Verified: | July 2014 |
18-F Sodium Fluoride Acute coronary syndrome Stable Angina |
Coronary Artery Disease Acute Coronary Syndrome Angina, Stable Coronary Disease Myocardial Ischemia Heart Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Angina Pectoris |
Chest Pain Pain Neurologic Manifestations Listerine Fluorides Sodium Fluoride Cariostatic Agents Protective Agents Physiological Effects of Drugs Anti-Infective Agents, Local Anti-Infective Agents |