Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Nichola Gale, Cardiff University Identifier:
First received: August 1, 2012
Last updated: July 27, 2015
Last verified: July 2015
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of cardiovascular disease,osteoporosis, muscle wasting and diabetes mellitus. Cardiovascular disease is a major cause of death in such patients and it may be related to excess stiffening of the walls of major arteries, such as the aorta, and it has been suggested to represent premature aging. However, there is little known of the development of these problems, which were previously considered to be due to smoking and which is now known not to be the only factor. The investigators will study a large group of patients with mild to very severe airflow obstruction based on the NICE 2010 classification of severity and a matched comparator group free of COPD. This study involves three assessments of the development of the complications of COPD over a five year period. The key measure will be the rate of change in the aortic wall stiffness, an accepted indicator of the risk of heart disease. Changes in wall stiffness will be related to the severity of lung disease; other known cardiovascular risk factors, such as high blood pressure, increased blood cholesterol and to cardiovascular events including heart attacks and death; and to the presence of other complications, such as osteoporosis, muscle wasting and diabetes mellitus. These measures will be analysed in the context of changes in bodywide inflammation and metabolic function and the changes in the rate of ageing. This increased knowledge of interacting factors in the complications of COPD is likely to lead to studies of treatments to avoid their development.

Chronic Obstructive Pulmonary Disease (COPD)

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE)

Resource links provided by NLM:

Further study details as provided by Cardiff University:

Primary Outcome Measures:
  • Aortic Pulse Wave Velocity (arterial stiffness) [ Time Frame: Baseline, 2 and 5 yrs ] [ Designated as safety issue: No ]
    Rate of change in aortic pulse wave velocity in patients with COPD over a period of 5 years and its relationship to cardiovascular morbidity and mortality.

Estimated Enrollment: 750
Study Start Date: May 2011
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Patients with Chronic Obstructive Pulmonary Disease, including mild, moderate, severe and very severe airflow obstruction
Current or ex-smokers free from from Respiratory Disease


Ages Eligible for Study:   35 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample

Inclusion Criteria:

  • Previously Proven COPD or at risk of developing COPD

Exclusion Criteria:

  • Pregnancy
  • A history of malignancy in the last 5 years
  • Unable to give informed consent or diagnosed dementia
  • Renal or hepatic failure
  • Active endocrine disorder eg., Addison's disease, hypothyroidism
  • Any other disease identified as having an inflammatory or metabolic component, eg. rheumatoid disease
  • Disorders affecting mobility, eg. Parkinson's disease, cerebrovascular accident.
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Please refer to this study by its identifier: NCT01656421

United Kingdom
Wales Heart Research Institute
Cardiff, United Kingdom, CF14 4XN
Sponsors and Collaborators
Cardiff University
Principal Investigator: Dennis J Shale, MD, FRCP Cardiff University
Principal Investigator: John R Cockcroft, MD, FRCP Cardiff University
  More Information

No publications provided by Cardiff University

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Nichola Gale, Research Associate, Cardiff University Identifier: NCT01656421     History of Changes
Other Study ID Numbers: SPON 87610, 10/CAD/4972
Study First Received: August 1, 2012
Last Updated: July 27, 2015
Health Authority: United Kingdom: Research Ethics Committee

Additional relevant MeSH terms:
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Lung Diseases
Respiratory Tract Diseases processed this record on November 25, 2015