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What is an Important Change in the Short Physical Performance Battery (SPPB)?

This study has been completed.
Information provided by (Responsible Party):
Royal Brompton & Harefield NHS Foundation Trust Identifier:
First received: July 9, 2012
Last updated: November 4, 2014
Last verified: November 2014
The purpose of this study is to determine the important change in the Short Physical Performance Battery (SPPB) when used in patients with lung disease. The SPPB is a simple physical test that measures balance and the functioning of the legs. It has been widely used in healthy elderly populations and predicts hospital admission and the onset of disability. The SPPB has not previously been used in patients with lung disease, and it is not clear what change in this test is considered meaningful and worthwhile by patients or doctors (the minimal clinically important difference: MID). Knowing what the MID for the SPPB will allow researchers and doctors to evaluate the effectiveness of current and new treatments, and to detect improvement or deterioration in the condition of patients.

Condition Intervention
Respiratory Tract Diseases
Lung Diseases
Other: Pulmonary rehabilitation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Determining the Minimal Important Difference of the Short Physical Performance Battery and 4m Gait Speed in Chronic Respiratory Disease Patients.

Resource links provided by NLM:

Further study details as provided by Royal Brompton & Harefield NHS Foundation Trust:

Primary Outcome Measures:
  • Change from baseline of Short Physical Performance Battery [ Time Frame: 8 weeks ]

Secondary Outcome Measures:
  • Change from baseline of MRC Dyspnoea Scale [ Time Frame: 8 weeks ]
  • Change from baseline of St George's Respiratory Questionaire [ Time Frame: 8 weeks ]
  • Anchor question (5-point Likert scale) [ Time Frame: 8 weeks ]

Biospecimen Retention:   Samples With DNA
Blood taken and stored as whole blood, serum, and plasma.

Enrollment: 400
Study Start Date: March 2012
Study Completion Date: May 2014
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Chronic Respiratory Disease
Any patient with a chronic respiratory disease referred for pulmonary rehabilitation
Other: Pulmonary rehabilitation
An eight week out-patient based programme consisting of twice weekly supervised exercise and educational sessions


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All chronic respiratory disease patients referred for pulmonary rehabilitation.

Inclusion Criteria:

  • All patients entering pulmonary rehabilitation

Exclusion Criteria:

  • Any patient in whom mobility and lower limb function have been significantly affected by a neuromuscular cause, severe peripheral vascular disease or amputation.
  • Any patient whom the chief investigator feels it is unsafe to exercise (e.g. unstable cardiac disease).
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Please refer to this study by its identifier: NCT01649193

United Kingdom
Harefield Hospital
Harefield, Middlesex, United Kingdom, UB9 6JH
Sponsors and Collaborators
Royal Brompton & Harefield NHS Foundation Trust
Principal Investigator: William DC Man, MRCP, PhD Repiratory Biomedical Reserach Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College London
  More Information

Responsible Party: Royal Brompton & Harefield NHS Foundation Trust Identifier: NCT01649193     History of Changes
Other Study ID Numbers: 2012LF001H
Study First Received: July 9, 2012
Last Updated: November 4, 2014

Keywords provided by Royal Brompton & Harefield NHS Foundation Trust:
Rehabilitation [E02.831]
Exercise [G11.427.394.380]
Health Education [I02.233.332]

Additional relevant MeSH terms:
Lung Diseases
Respiratory Tract Diseases processed this record on May 25, 2017