Analysis of Visual Pathways in Glaucoma Patients Using a 3tesla-MRI (ENVOL)
Glaucoma is a neurodegenerative disease representing the second cause of blindness worldwide. IOP (Intra occular pressure) is the most common risk factor, but not the only one as it is observed for normal tension glaucoma. Some studies have reported lesions of the optical pathways on MRI examination MRI 3T (Magnetic Resonance Imaging 3 Telsa), by increasing spatial resolution and DTI (diffusion tensor Imaging)with fractional anisotropy could help us to analyze visual pathways and to determine the association with neurodegenerative diseases as Alzheimer.
The investigators propose to compare volume and structure of the visual pathways between glaucoma patients and healthy subjects matched on age and sex.
Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells, visual field deterioration and optic nerve cupping. Some studies have suggested that all the visual pathways could be damaged in glaucoma. Recently, a German study proved a significant reduction of volume of the optic radiations in glaucoma versus healthy subjects in MRI 3T. Some authors have also suggested that glaucoma could share similarities with the other neurodegenerative diseases like Alzheimer's disease. MRI 3T and DTI allow studying visual pathways with a high level of spatial resolution.Fractional anisotropy is a tag of microstructure.
|Glaucoma Fractional Anisotropy|
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
- fractional anisotropy [ Time Frame: Inclusion ]
- volume of retrochiasmatic grey matter [ Time Frame: Inclusion ]
- global atrophy [ Time Frame: inclusion ]
- hyper intensities white matter [ Time Frame: inclusion ]
|Study Start Date:||June 2012|
|Study Completion Date:||November 2013|
|Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01621841
|Service d'ophtalmologie Hôpital Pellegrin|
|CHU de Bordeaux, Bordeaux, France, 33000|