Brain Stimulation and Vision Testing
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|ClinicalTrials.gov Identifier: NCT01617408|
Recruitment Status : Recruiting
First Posted : June 12, 2012
Last Update Posted : September 14, 2021
- The brain has two systems for recognizing objects. One system recognizes what an object is, and the other system recognizes where the object is located. However, there is much about how the brain handles and interprets the information from these two systems that is still unclear. Researchers want to study the parts of the brain that are involved in how vision is processed. They will use magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS) on the brain. MRI measures what parts of the brain become more active when tasks are performed. TMS uses magnetic pulses to temporarily change the activity in parts of the brain.
- To better understand how people visually recognize different types of objects.
- Healthy volunteers between 18 and 50 years of age.
- This study includes many different experiments on vision. Each experiment may combine visual tasks, MRI scans, and TMS. Participants may be asked to have several different tests. Each test will require a separate visit to the National Institutes of Health.
- Participants will be screened with a physical exam and medical history. They will have a baseline brain scan at the first visit.
- Participants may do visual tasks alone, with MRI only, with TMS only, or with MRI and TMS combined. For the visual tasks, they will look at pictures of objects on a computer screen. Sometimes the images will appear very briefly (less than one-tenth of a second). Sometimes they will appear for up to 5 seconds. These images will be of things like faces, bodies, tools, and scenes. Participants will be asked to respond in different ways to the pictures. They may respond by typing on a computer keyboard or by pressing a button. Participants will have time to practice the tasks before the experiment.
- Participants will remain on the study for up to 3 years.
|Condition or disease|
|Transcranial Magnetic Stimulation (TMS) Visual System fMRI Dorsal Pathway Ventral Pathway|
|Study Type :||Observational|
|Estimated Enrollment :||345 participants|
|Official Title:||TMS Investigations of the Human Visual System|
|Actual Study Start Date :||March 4, 2013|
Neurologically normal subjects aged 18 to 50 years old
- Online behavioral TMS experiments: performance accuracy, sensitivity and reaction time (RT); Offline fMRI TBS experiments: taskperformance as well as reduced neuronal activity [ Time Frame: Ongoing ]a. Behavioral TMS experiments will measure the speed of a key press to indicate the correct answer and performance accuracy onthe task.b. Offline TMS that combine TBS with fMRI will measure changes in BOLD activation in the targeted region as well as in connected cortical areas identified with an independent localizer.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01617408
|Contact: NIMH LBC Volunteer||(301) email@example.com|
|Contact: Christopher I Baker, Ph.D.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 email@example.com|
|Principal Investigator:||Christopher I Baker, Ph.D.||National Institute of Mental Health (NIMH)|