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Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC

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ClinicalTrials.gov Identifier: NCT01608945
Recruitment Status : Suspended
First Posted : May 31, 2012
Last Update Posted : May 31, 2012
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage. The aim of this prospective, randomized study was to determine whether steroid administration can reduce liver injury and impact the prognosis

Condition or disease Intervention/treatment
Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver Drug: Hydrocortisone sodium succinate

Study Design

Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : April 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
steroid,liver function I/R Drug: Hydrocortisone sodium succinate
100mg/day


Outcome Measures

Primary Outcome Measures :
  1. liver function [ Time Frame: six months ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
60
Criteria

Inclusion Criteria:

  • 18-70 years old
  • diametre of the mass>3cm.
  • hcc
More Information

Responsible Party: jian zhai, hepatic department, Eastern Hepatobiliary Surgery Hospital
ClinicalTrials.gov Identifier: NCT01608945     History of Changes
Other Study ID Numbers: EHBH112
First Posted: May 31, 2012    Key Record Dates
Last Update Posted: May 31, 2012
Last Verified: May 2012

Keywords provided by jian zhai, Eastern Hepatobiliary Surgery Hospital:
steroid
liver function
prognosis

Additional relevant MeSH terms:
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Cortisol succinate
Hydrocortisone
Anti-Inflammatory Agents