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Effect of Caloric Restriction and Gastric Bypass on Resting Metabolic Rate

This study has been terminated.
Hospital Barmherzige Schwestern Vienna
Information provided by (Responsible Party):
KiloCoach e.U. Identifier:
First received: May 9, 2012
Last updated: February 4, 2015
Last verified: February 2015
Studies in overweight and obese subjects show a decline in resting metabolic rate (RMR) even after moderate caloric restriction. Yet the onset and course of such a metabolic adaption is still unclear. Lower resting metabolic rates were also reported after gastric banding bariatric surgery but have not yet been investigated in subjects after gastric bypass. The purpose of this study is to investigate the consequences on resting metabolic rate in subjects with obesity after moderate caloric restriction or gastric bypass.

Condition Intervention
Procedure: Gastric bypass
Behavioral: Caloric restriction

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effect of Caloric Restriction and Gastric Bypass on Resting Metabolic Rate in Obese Subjects

Further study details as provided by KiloCoach e.U.:

Primary Outcome Measures:
  • Resting metabolic rate [ Time Frame: 24 weeks ]

Secondary Outcome Measures:
  • Body composition (muscle mass, fat mass) [ Time Frame: 24 weeks ]
  • Body Mass Index [ Time Frame: 24 weeks ]
  • Caloric restriction [ Time Frame: 24 weeks ]
  • Weight loss [ Time Frame: 24 weeks ]

Estimated Enrollment: 75
Study Start Date: April 2012
Estimated Study Completion Date: February 2015
Estimated Primary Completion Date: February 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Gastric bypass
Subjects with planned gastric bypass surgery are followed-up in regard of resting metabolic rate.
Procedure: Gastric bypass
Subjects with a planned gastric bypass surgery are followed-up for resting metabolic rate.
Caloric restriction
Caloric restriction calculated by an online weight management program (based on subject's starting weight, start BMI, age, target weight and time span). Subjects are followed-up in regard to resting metabolic rate.
Behavioral: Caloric restriction
Subjects receive caloric restriction as calculated by an online weight management program and are followed-up for resting metabolic rate.


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • BMI ≥30 kg/m2

Exclusion Criteria:

  • Marked weight reduction in the last 2 years (>5% of initial body weight)
  • Recent extreme fasting (during the last month)
  • Manifest eating disorders (assignment to a specialist for eating disorders)
  • Severe psychiatric disorders requiring treatment
  • Pregnancy, lactation
  Contacts and Locations
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Please refer to this study by its identifier: NCT01595945

Hospital Barmherzige Schwestern Vienna
Vienna, Austria, 1060
KiloCoach e.U.
Vienna, Austria, 1060
Sponsors and Collaborators
KiloCoach e.U.
Hospital Barmherzige Schwestern Vienna
Study Director: Rosa Aspalter, MD. KiloCoach e.U.
  More Information

Responsible Party: KiloCoach e.U. Identifier: NCT01595945     History of Changes
Other Study ID Numbers: KCKBHS-01
Study First Received: May 9, 2012
Last Updated: February 4, 2015

Keywords provided by KiloCoach e.U.:
Caloric restriction
Gastric bypass
Resting metabolic rate processed this record on May 23, 2017