Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes
Recruitment status was: Recruiting
Concussed athlethes have discrete decreased abilities in motor learning. Recent research could further show, that cortical plasticity, as measured by transcranial magnetic stimulation (TMS) is reduced. This is possibly due to an increased GABAergic activity, what have been found in concussed athletes by paired pulse protocols in TMS.
GABAergic acitivty can be modulated by transcranial direct current stimulation (tDCS) in a polar-specific manner: anodal tDCS was able to decrease GABA, whereas cathodal tDCS increased tDCS.
Our study aimes to assess the influence of anodal tDCS on cortical plsticity in concussed athlethes. We hypothesize, that anodal tDCS is able to increase cortical plsticity in concussed athlethes.
|Study Design:||Endpoint Classification: Efficacy Study
Primary Purpose: Treatment
|Official Title:||Influence of Anodal Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes and Healthy Volunteers|
- Improvement of cortical plasticity after anodal tDCS in concussed athletes
|Study Start Date:||March 2012|
|Estimated Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01593956
|Charité - Department of neurology|
|Berlin, Germany, 10117|
|Principal Investigator:||Jonathan List, MD||Charité - Department of Neurology|
|Principal Investigator:||Agnes Flöel, Prof.||Charité - Department of Neurology|