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Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes

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ClinicalTrials.gov Identifier: NCT01593956
Recruitment Status : Unknown
Verified May 2013 by Jonathan List, Charite University, Berlin, Germany.
Recruitment status was:  Recruiting
First Posted : May 8, 2012
Last Update Posted : May 23, 2013
Sponsor:
Information provided by (Responsible Party):
Jonathan List, Charite University, Berlin, Germany

Study Description
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Brief Summary:

Concussed athlethes have discrete decreased abilities in motor learning. Recent research could further show, that cortical plasticity, as measured by transcranial magnetic stimulation (TMS) is reduced. This is possibly due to an increased GABAergic activity, what have been found in concussed athletes by paired pulse protocols in TMS.

GABAergic acitivty can be modulated by transcranial direct current stimulation (tDCS) in a polar-specific manner: anodal tDCS was able to decrease GABA, whereas cathodal tDCS increased tDCS.

Our study aimes to assess the influence of anodal tDCS on cortical plsticity in concussed athlethes. We hypothesize, that anodal tDCS is able to increase cortical plsticity in concussed athlethes.


Condition or disease Intervention/treatment Phase
Concussed Athletes Healthy Controls Behavioral: tDCS Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Primary Purpose: Treatment
Official Title: Influence of Anodal Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes and Healthy Volunteers
Study Start Date : March 2012
Estimated Primary Completion Date : July 2013
Arms and Interventions
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Arm Intervention/treatment
Concussed athletes Behavioral: tDCS
Healthy controls Behavioral: tDCS


Outcome Measures
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Primary Outcome Measures :
  1. Improvement of cortical plasticity after anodal tDCS in concussed athletes

Eligibility Criteria
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • history of at least 2 sports concussion
  • age 18 - 50 years

Exclusion Criteria:

  • structural deficit on cerebral MRI
  • Epilepsy
  • neurological disorder
  • intake of CNS-active drugs
Contacts and Locations
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01593956


Locations
Germany
Charité - Department of neurology Recruiting
Berlin, Germany, 10117
Contact: Jonathan List, MD    +40 30 450560223    Jonathan.List@charite.de   
Contact: Agnes Flöel, Prof.    +40 30 450660284    agnes.floeel@charite.de   
Principal Investigator: Jonathan List, MD         
Principal Investigator: Agnes Flöel, Prof         
Sponsors and Collaborators
Charite University, Berlin, Germany
Investigators
Principal Investigator: Jonathan List, MD Charité - Department of Neurology
Principal Investigator: Agnes Flöel, Prof. Charité - Department of Neurology
More Information
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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications:

Responsible Party: Jonathan List, MD, Charite University, Berlin, Germany
ClinicalTrials.gov Identifier: NCT01593956     History of Changes
Other Study ID Numbers: EA1/021/12
First Posted: May 8, 2012    Key Record Dates
Last Update Posted: May 23, 2013
Last Verified: May 2013