Renal Acute MI Study
The purpose of this study is to determine if a sizable myocardial infarction (heart attack) results in negative changes to renal structure and function (i.e. has a negative impact on the kidneys).
To determine if the renal response to a myocardial infarction is a predictor of the patients future health.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Renal Structural, Functional and Cytokine Responses to Acute Myocardial Injury in Man|
- changes in renal function and structure [ Time Frame: Baseline, discharge, 1 month, 6 months and 12 months ] [ Designated as safety issue: No ]
- renal response to myocardial infarction [ Time Frame: baseline, discharge, 1 month, 6 months and 12 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||March 2012|
|Estimated Study Completion Date:||December 2016|
|Estimated Primary Completion Date:||December 2016 (Final data collection date for primary outcome measure)|
Group 1 - Control
Non-Q wave MI subjects with normal cardiac and renal function (defined as eGFR >60ml/min) not undergoing a cardiac procedure involving contrast will serve as "control" for renal injury subjects.
Group 2 - stable CAD or non-Q wave MI
Patients undergoing coronary angiography +/- PCI for stable CAD or non-Q wave MI with normal cardiac and renal function (defined as eGFR >60ml/min) will control for the contrast STEMI patients are likely to receive as part of their post-MI management
Group 3 - Acute STEMI without chronic kidney disease
Acute STEMI patients (n=40), without chronic kidney disease (defined as eGFR ≥60ml/min).
Group 4 - Acute STEMI with kidney disease
Acute STEMI patients (n=40), with evidence of background chronic kidney disease (eGFR <60ml/min).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01580566
|Contact: Henry Krum, MBBS FRACP PhD||+613 9903 firstname.lastname@example.org|
|Melbourne, Victoria, Australia, 3004|
|Contact: Henry Krum, MBBS FRACP PhD +613 9903 0042 email@example.com|
|Principal Investigator: Henry Krum, MBBS FRACP PhD|
|Principal Investigator:||Henry Krum, MBBS FRACP PhD||Alfred Hospital/Monash.University|
|Principal Investigator:||Henry Krum, MBBS FRACP PhD||Alfred Hospital/Monash University|