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Effects of Berries on Post-meal Blood Sugar (SOMA)

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ClinicalTrials.gov Identifier: NCT01580150
Recruitment Status : Completed
First Posted : April 18, 2012
Last Update Posted : April 18, 2012
Sponsor:
Information provided by (Responsible Party):
Marjukka Kolehmainen, University of Eastern Finland

Brief Summary:
The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

Condition or disease Intervention/treatment Phase
Blood Glucose, Postprandial Blood Insulin, Postprandial Hyperglycemia Other: Berries Other: No berries Not Applicable

Detailed Description:

Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.

The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

  • Studies 1-2: white wheat bread (starch) is consumed with several berry species
  • Study 3: white wheat bread or rye bread is consumed with a mixture of berries
  • Study 4: sugar (sucrose) is consumed with berries and berry nectars
  • Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch
Study Start Date : November 2009
Actual Primary Completion Date : January 2012
Actual Study Completion Date : January 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Blood Sugar

Arm Intervention/treatment
Experimental: Berry meal
Carbohydrate meals with berries
Other: Berries
Meals containing starch (bread) or sucrose are consumed with berries (150 g) or berry nectars (300 mL).

Active Comparator: Reference meal
Carbohydrate meals without berries
Other: No berries
Meals containing starch (bread) or sucrose are consumed without berries.




Primary Outcome Measures :
  1. Plasma glucose [ Time Frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal ]
  2. Plasma insulin [ Time Frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal ]

Secondary Outcome Measures :
  1. Plasma free fatty acids [ Time Frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal ]


Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 69 Years   (Adult, Older Adult)
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI 20-28 kg/m2
  • normal fasting plasma glucose

Exclusion Criteria:

  • Smoking
  • Diabetes or other chronic disease
  • Antibiotic medication within the past 3 months
  • Blood donation within the past month

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01580150


Locations
Finland
University of Eastern Finland
Kuopio, Finland, FI-70211
Sponsors and Collaborators
Marjukka Kolehmainen
Investigators
Principal Investigator: Riitta Törrönen, Dr Senior Scientist

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Marjukka Kolehmainen, Senior scientist, University of Eastern Finland
ClinicalTrials.gov Identifier: NCT01580150     History of Changes
Other Study ID Numbers: 247032
70035/09, 1087/31/2009 ( Other Grant/Funding Number: Tekes )
First Posted: April 18, 2012    Key Record Dates
Last Update Posted: April 18, 2012
Last Verified: April 2012

Keywords provided by Marjukka Kolehmainen, University of Eastern Finland:
Berries
Starch
Sucrose
Glucose
Insulin
Postprandial

Additional relevant MeSH terms:
Hyperglycemia
Glucose Metabolism Disorders
Metabolic Diseases