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Obstructive Sleep Apnea in Pulmonary Embolism

This study has been completed.
Information provided by (Responsible Party):
meral uyar, University of Gaziantep Identifier:
First received: April 16, 2012
Last updated: April 17, 2012
Last verified: April 2012
Obstructive sleep apnea (OSA) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep. Repeated episodes of hypoxia, decrease in intrathoracic pressure, increased venous return and venous stasis, damage to vascular wall may ensue. An increased tendency for coagulation has also been reported in OSA. Venous stasis, vascular endothelial activation and hypercoagulability are also known risk factors for thromboembolism. All of these pathophysiologic changes in OSA may predispose patients for the development of pulmonary embolism (PE) however there is limited data about role of thromboembolic events in OSA.

Condition Intervention
Pulmonary Thromboembolism Obstructive Sleep Apnea Other: polysomnography

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Obstructive Sleep Apnea is Prevalent in Patients With Pulmonary Embolism

Resource links provided by NLM:

Further study details as provided by meral uyar, University of Gaziantep:

Enrollment: 75
Study Start Date: November 2009
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Pulmonary embolism
Patients who were diagnosed with pulmonary embolism
Other: polysomnography
full night supervised laboratory polysomnography
Other Name: PSG
control group
age and sex matched adults with osa and no thromboembolism
Other: polysomnography
full night supervised laboratory polysomnography
Other Name: PSG


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All subjects admitted to Department of Pulmonary Medicine of Gaziantep University who were diagnosed to have PE were included in the study group. Control group consisted of age and sex matched subjects without a clinic consistent with PE referred to the Sleep Clinic. PE was diagnosed when one or more of the following was present: compatible physical examination findings and multislice CT angiography or presence of deep venous thrombus (DVT) in addition to high risk with Wells criteria [5]. Subjects with any restrictive/obstructive lung pathology or younger than 18 years old were excluded.

Inclusion Criteria:

  • All consecutive patients diagnosed with pulmonary embolism

Exclusion Criteria:

  • less than 18 years of age
  • any restrictive or obstructive lung disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01580085

University of Gaziantep Hospital
Gaziantep, Turkey, 27310
Sponsors and Collaborators
University of Gaziantep
Principal Investigator: Meral Uyar, Assist Prof University of Gaziantep
  More Information

Responsible Party: meral uyar, Asisstant Professor, University of Gaziantep Identifier: NCT01580085     History of Changes
Other Study ID Numbers: gantep gogus 1
Study First Received: April 16, 2012
Last Updated: April 17, 2012

Keywords provided by meral uyar, University of Gaziantep:
Sleep disordered breathing

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Pulmonary Embolism
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases processed this record on August 22, 2017