Obstructive Sleep Apnea in Pulmonary Embolism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01580085
Recruitment Status : Completed
First Posted : April 18, 2012
Last Update Posted : April 18, 2012
Information provided by (Responsible Party):
meral uyar, University of Gaziantep

Brief Summary:
Obstructive sleep apnea (OSA) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep. Repeated episodes of hypoxia, decrease in intrathoracic pressure, increased venous return and venous stasis, damage to vascular wall may ensue. An increased tendency for coagulation has also been reported in OSA. Venous stasis, vascular endothelial activation and hypercoagulability are also known risk factors for thromboembolism. All of these pathophysiologic changes in OSA may predispose patients for the development of pulmonary embolism (PE) however there is limited data about role of thromboembolic events in OSA.

Condition or disease Intervention/treatment
Pulmonary Thromboembolism Obstructive Sleep Apnea Other: polysomnography

Study Type : Observational
Actual Enrollment : 75 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Obstructive Sleep Apnea is Prevalent in Patients With Pulmonary Embolism
Study Start Date : November 2009
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort Intervention/treatment
Pulmonary embolism
Patients who were diagnosed with pulmonary embolism
Other: polysomnography
full night supervised laboratory polysomnography
Other Name: PSG
control group
age and sex matched adults with osa and no thromboembolism
Other: polysomnography
full night supervised laboratory polysomnography
Other Name: PSG

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All subjects admitted to Department of Pulmonary Medicine of Gaziantep University who were diagnosed to have PE were included in the study group. Control group consisted of age and sex matched subjects without a clinic consistent with PE referred to the Sleep Clinic. PE was diagnosed when one or more of the following was present: compatible physical examination findings and multislice CT angiography or presence of deep venous thrombus (DVT) in addition to high risk with Wells criteria [5]. Subjects with any restrictive/obstructive lung pathology or younger than 18 years old were excluded.

Inclusion Criteria:

  • All consecutive patients diagnosed with pulmonary embolism

Exclusion Criteria:

  • less than 18 years of age
  • any restrictive or obstructive lung disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01580085

University of Gaziantep Hospital
Gaziantep, Turkey, 27310
Sponsors and Collaborators
University of Gaziantep
Principal Investigator: Meral Uyar, Assist Prof University of Gaziantep

Responsible Party: meral uyar, Asisstant Professor, University of Gaziantep Identifier: NCT01580085     History of Changes
Other Study ID Numbers: gantep gogus 1
First Posted: April 18, 2012    Key Record Dates
Last Update Posted: April 18, 2012
Last Verified: April 2012

Keywords provided by meral uyar, University of Gaziantep:
Sleep disordered breathing

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Pulmonary Embolism
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases