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Zinc Absorption From Zinc Citrate, Zinc Gluconate and Zinc Oxide

This study has been completed.
University of Zurich
Information provided by (Responsible Party):
Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology Identifier:
First received: April 4, 2012
Last updated: January 3, 2013
Last verified: January 2013
The goal of this trial is to evaluate zinc citrate, a zinc compound with promising sensory properties and a high zinc content, as an alternative zinc compound to be used for supplementation or food fortification. The bioavailability of zinc citrate given as a supplement to young Swiss adults will be assessed and compared to the bioavailability of the commonly used zinc compounds zinc gluconate and zinc oxide.

Condition Intervention
Dietary Supplement: zinc citrate
Dietary Supplement: Zinc Gluconate
Dietary Supplement: Zinc oxide

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Official Title: Zinc Absorption From Zinc Supplements Comparing Zinc Citrate to Zinc Gluconate and Zinc Oxide in Young Adults

Resource links provided by NLM:

Further study details as provided by Swiss Federal Institute of Technology:

Primary Outcome Measures:
  • Fractional absorption of zinc [ Time Frame: 61 days ]
    Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.

Enrollment: 15
Study Start Date: March 2012
Study Completion Date: November 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: zinc citrate Dietary Supplement: zinc citrate
10 mg of zinc as either zinc citrate
Active Comparator: zinc gluconate Dietary Supplement: Zinc Gluconate
10 mg of zinc as either zinc gluconate
Active Comparator: zinc oxide Dietary Supplement: Zinc oxide
10 mg of zinc as either zinc oxide


Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male or female of 18 to 45 years old
  • Body Mass Index in the range of 19 to 25
  • No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion Criteria:

  • Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
  • Long-term medication during the whole study (except for contraceptives)
  • Vegans
  • Pregnancy
  • Lactation
  • Intention to become pregnant during the course of the study
  • Lack of safe contraception
  • Consumption of mineral and vitamin supplements within 2 weeks prior to 1st test supplement administration
  • Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study
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Please refer to this study by its identifier: NCT01576627

ETH Zurich
Zurich, Switzerland, 8092
Sponsors and Collaborators
Prof. Michael B. Zimmermann
University of Zurich
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Prof. Michael B. Zimmermann, Prof, Swiss Federal Institute of Technology Identifier: NCT01576627     History of Changes
Other Study ID Numbers: HNL/CTC11-12
Study First Received: April 4, 2012
Last Updated: January 3, 2013

Additional relevant MeSH terms:
Zinc Oxide
Citric Acid
Dermatologic Agents
Sunscreening Agents
Radiation-Protective Agents
Protective Agents
Physiological Effects of Drugs
Calcium Chelating Agents
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action
Trace Elements
Growth Substances processed this record on April 28, 2017