Predicting Treatment Response Using Psychophysiologic Reactivity Measures
Objective psychophysiologic reactivity data may be useful for predicting post-traumatic stress disorder (PTSD) treatment response. Given the variety of PTSD treatments and the lack of a clearly superior treatment, a reliable and valid approach to predicting treatment response is needed.
Specific Aims: 1). Evaluate the clinical utility of psychophysiologic reactivity measures to predict overall PTSD symptom response among OEF/OIF/OND (Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn) veterans receiving treatment for PTSD. 2). Evaluate the clinical utility of psychophysiologic reactivity measures to predict psychosocial functioning and health-related quality of life (HRQoL) response among OEF/OIF/OND veterans in treatment for PTSD. Exploratory). Develop psychophysiologic, neuropsychological, and/or self-report models to predict PTSD symptom response to pharmacotherapy, psychotherapy, and combined pharmacotherapy/psychotherapy. We will divide psychophysiologic reactivity predictors into two groups: heart rate variability and attentional bias (eye gaze tracking and modified Stroop). We will collect observational and longitudinal data from a treatment-seeking sample of 50 OEF/OIF/OND veterans with PTSD recruited from the Central Arkansas Veterans Healthcare System (CAVHS) Mental Health Clinics.
Post Traumatic Stress Disorder
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Predicting Treatment Response Using Psychophysiologic Reactivity Measures|
- Change in Eye-gaze Tracking [ Time Frame: from Baseline to 6 months ] [ Designated as safety issue: No ]This measures attentional bias.
- Change in Modified Stroop [ Time Frame: from Baseline to 6 months ] [ Designated as safety issue: No ]This measures attentional bias
- Change in Heart rate variability [ Time Frame: from Baseline to 6 months ] [ Designated as safety issue: No ]
|Study Start Date:||April 2012|
|Estimated Study Completion Date:||April 2016|
|Estimated Primary Completion Date:||April 2015 (Final data collection date for primary outcome measure)|
Veterans with PTSD
Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) veterans who are ages 18 to 60 and currently in or about to start treatment for deployment-related Post-Traumatic Stress Disorder (PTSD) at the Central Arkansas Veterans Healthcare System Mental Health Clinics.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01571245
|Contact: Tim Kimbrell, MDfirstname.lastname@example.org|
|Contact: Jeffrey M Pyne, MDemail@example.com|
|United States, Arkansas|
|CAVHS Eugene Towbin VA Medical Center||Recruiting|
|North Little Rock, Arkansas, United States, 72114-1706|
|Contact: Susan M Jegley, LMSW 501-257-1731 firstname.lastname@example.org|
|Principal Investigator: Tim Kimbrell, MD|
|Sub-Investigator: Jeffrey M Pyne, MD|
|Sub-Investigator: John Spollen, MD|
|Sub-Investigator: Dinesh Mittal, MD|
|Principal Investigator:||John Spollen, MD||Central Arkansas Veterans Healthcare System|