Adipokines and the Risk of Reflux Esophagitis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01560598
Recruitment Status : Unknown
Verified March 2012 by Donghee Kim, Seoul National University Hospital.
Recruitment status was:  Not yet recruiting
First Posted : March 22, 2012
Last Update Posted : March 22, 2012
Information provided by (Responsible Party):
Donghee Kim, Seoul National University Hospital

Brief Summary:
We aimed to risk faoctors for GERD and association between visceral obesity, plasma adipoline(leptin, adiponectin, IL-6, TNF-α)and development of reflux esophagitis in healthy Koreans.

Condition or disease
Visceral Obesity Reflux Esophagitis

Study Type : Observational
Estimated Enrollment : 600 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Adipokines and the Risk of Reflux Esophagitis : Prospective Case-control Study
Study Start Date : June 2012
Estimated Primary Completion Date : June 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: GERD

Reflux esophagitis
those with endoscopically proven reflux esophagitis
those with normal GFS finding (without definite mucosal break at Z-line)

Primary Outcome Measures :
  1. Difference in serum adipokine levels between case and control groups [ Time Frame: 2 month lager (after sampling) ]

Biospecimen Retention:   Samples Without DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
healthy adults who visit healthcare system for routine checkup

Inclusion Criteria:

  • endoscopically proven reflux esophagitis

Exclusion Criteria:

  • those with esophageal hiatal hernia, current PPI medication, upper GI operation history

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01560598

Contact: Kyung-Sang Yu, Professor +82-2-2072-1920
Contact: Jeong-Hwa Hong, IRB analyst +82-2-740-8096

Korea, Republic of
Seoul National University Hospital Healthcare System Gangnam Center Not yet recruiting
Seoul, Korea, Republic of
Contact: Su Jin Chung, MD    +82-10-8424-8471   
Principal Investigator: Donghee Kim, MD         
Sponsors and Collaborators
Seoul National University Hospital

Responsible Party: Donghee Kim, Clinical Assistant Professor, Seoul National University Hospital Identifier: NCT01560598     History of Changes
Other Study ID Numbers: gerdadipokine
First Posted: March 22, 2012    Key Record Dates
Last Update Posted: March 22, 2012
Last Verified: March 2012

Keywords provided by Donghee Kim, Seoul National University Hospital:
reflux esophagitis
endoscopically proven

Additional relevant MeSH terms:
Gastroesophageal Reflux
Esophagitis, Peptic
Obesity, Abdominal
Esophageal Motility Disorders
Deglutition Disorders
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Peptic Ulcer
Duodenal Diseases
Intestinal Diseases
Stomach Diseases
Nutrition Disorders