Tissue and Plasma Biomarkers of Lymph Node Involvement in Cervical Cancer
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|ClinicalTrials.gov Identifier: NCT01546363|
Recruitment Status : Recruiting
First Posted : March 7, 2012
Last Update Posted : May 9, 2017
|Condition or disease||Intervention/treatment|
|Cervical Cancer||Other: Blood draw|
SPECIFIC STUDY AIMS
Specific Aim 1: To use gene expression analysis of primary cervical cancers to identify a gene expression signature that predicts for lymph node metastases in this disease.
Specific Aim 2: To predict lymph node metastases by performing multiplex measurements of cancer-associated proteins and cytokines using proximity ligation assay (PLA) on plasma samples.
Specific Aim 3: To measure circulating human papilloma virus (HPV) DNA in the plasma samples of cervical cancer patients using real-time quantitative polymerase chain reaction (qPCR) and determine its ability to predict for nodal metastases.
Specific Aim 4: To use deep sequencing to evaluate gene and sequence differences between cervical cancer patients with and without lymph node metastasis.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Tissue and Plasma Biomarkers of Lymph Node Involvement in Cervical Cancer|
|Study Start Date :||February 2012|
|Estimated Primary Completion Date :||January 1, 2019|
|Estimated Study Completion Date :||January 1, 2019|
Other: Blood draw
Other: Blood draw
- Biomarkers (genes and proteins) of lymph node involvement [ Time Frame: 4 years ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01546363
|Contact: Dylann Fujimotoemail@example.com|
|United States, California|
|Stanford University, School of Medicine||Recruiting|
|Stanford, California, United States, 94305|
|Contact: Dylann Fujimoto 650-723-8843 firstname.lastname@example.org|
|Sub-Investigator: Albert Koong, MD|
|Principal Investigator:||Elizabeth Kidd, MD||Stanford University|