Efficacy Study of Transcranial Magnetic Stimulation for Treatment of Obsessive-Compulsive Disorder
|ClinicalTrials.gov Identifier: NCT01540305|
Recruitment Status : Completed
First Posted : February 28, 2012
Last Update Posted : February 28, 2012
|Condition or disease||Intervention/treatment||Phase|
|Obsessive Compulsive Disorder||Device: Repetitive Transcranial Magnetic Stimulation (rTMS) Device: Sham repetitive transcranial magnetic stimulation||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||A Randomized Double-blind Trial of Repetitive Transcranial Magnetic Stimulation in Obsessive -Compulsive Disorder With Three Months Follow-up|
|Study Start Date :||May 2011|
|Actual Primary Completion Date :||September 2011|
|Actual Study Completion Date :||September 2011|
Active Comparator: Transcranial Magnetic Stimulation
Actual transcranial magnetic stimulation of supplementary motor areas bilaterally.
Device: Repetitive Transcranial Magnetic Stimulation (rTMS)
rTMS was administered by means of a NEURO-MS (NEUROSOFT LTD®, Russia) with a focal 8-shaped 70 mm coil. Stimulation parameters were 1-Hz, 20-min trains (1200 pulses/day) at 100% of resting MT, once a day, 5 days a week, for 2 weeks.
Other Name: Neuro-MS Transcranial Magnetic Stimulator
Sham Comparator: Sham Transcranial Magnetic Stimulation
Sham transcranial magnetic stimulation over the supplementary motor areas.
Device: Sham repetitive transcranial magnetic stimulation
The sham treatment was performed using the Neurosoft ® sham coil. A metal plate placed inside this coil prevents the magnetic field from stimulating the cortex. This coil looks and sounds like an active coil.
Other Name: Neurosoft sham coil
- Changes in Y-BOCS scale scores relative to baseline [ Time Frame: assessments were at baseline, at 2 weeks and at 3 months ]Y-BOCS: Yale-Brown Obsessive-Compulsive Scale
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01540305
|Laboratory of Neurosciences and Behavior, Biology Institute, University of Brasília|
|Brasília, DF, Brazil, 70000-000|
|Study Director:||Joaquim Brasil-Neto, MD, PhD||University of Brasilia|