Exercise, Glucose Kinetics, and the Incretin Effect
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ClinicalTrials.gov Identifier: NCT01607931 |
Recruitment Status
:
Completed
First Posted
: May 30, 2012
Last Update Posted
: August 12, 2016
|
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Human volunteers will be stratified by oral glucose tolerance status: normal glucose tolerant, impaired glucose tolerant, and type 2 diabetic. All subjects will undergo 4 experimental trials: [1] an oral glucose tolerance test (OGTT) combined with infused and ingested stable isotopes of glucose to assess glucose kinetics. [2] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by the same OGTT combined with stable isotope glucose tracers used in trial 1. [3] an isoglycemic clamp to match the plasma glucose profile measured in trial 1. [4] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by an isoglycemic clamp to match the plasma glucose profile measured in trial 2.
Exercise-induced changes in oral glucose tolerance, glucose kinetics, insulin and glucagon secretion, and the incretin effect will be examined. The exercise responses will be compared between the subjects groups of different glucose tolerance status.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Type 2 Diabetes | Behavioral: Exercise | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 12 participants |
Allocation: | Non-Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | The Effects of Acute Exercise on Glucose Kinetics, Beta-cell Function and the Incretin Effect in Subjects Representative of the Whole Glucose Tolerance Continuum |
Study Start Date : | January 2013 |
Actual Primary Completion Date : | April 2016 |
Actual Study Completion Date : | July 2016 |

Arm | Intervention/treatment |
---|---|
No Intervention: Resting Trial
a 1 hour period of rest immediately prior to OGTT or isoglycemic clamp
|
|
Experimental: Exercise Trial
a 1 hour cycling exercise bout immediately prior to the OGTT or isoglycemic clamp
|
Behavioral: Exercise
1 hour of cycling at 50% of maximum power output
|
- Glucose tolerance [ Time Frame: Plasma glucose will be measured at 10 minute intervals during the OGTT (3 hours) immediately following the period of rest or exercise ]
- Incretin effect [ Time Frame: Plasma insulin and C-peptide will be measured at 10 minute intervals during the OGTT (3 hours) and isoglycemic clamp (3 hours) immediately following the period of rest or exercise ]

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Ages Eligible for Study: | 18 Years to 60 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- age 18-60 years
- BMI 18-35 kg/m2
Exclusion Criteria:
- insulin dependency
- pregnancy
- presence or history of chronic cardiovascular, pulmonary, hepatic, renal, or hematological disease, or cancer
- contraindication to physical activity as assessed by ECG

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01607931
Denmark | |
Rigshospitalet | |
Copenhagen, Denmark |
Responsible Party: | Thomas Solomon, Senior Researcher, Rigshospitalet, Denmark |
ClinicalTrials.gov Identifier: | NCT01607931 History of Changes |
Obsolete Identifiers: | NCT01540097 |
Other Study ID Numbers: |
EFSD-2012 |
First Posted: | May 30, 2012 Key Record Dates |
Last Update Posted: | August 12, 2016 |
Last Verified: | August 2016 |
Keywords provided by Thomas Solomon, Rigshospitalet, Denmark:
Exercise Physical activity Type 2 diabetes Obesity Incretin effect GLP-1 |
GIP Insulin secretion Glucagon Beta-cell function Disposition Index |
Additional relevant MeSH terms:
Diabetes Mellitus, Type 2 Diabetes Mellitus Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases |
Incretins Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Physiological Effects of Drugs |