MRI Assessment of Leukemia Response to Therapy
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|ClinicalTrials.gov Identifier: NCT01537159|
Recruitment Status : Recruiting
First Posted : February 23, 2012
Last Update Posted : August 4, 2017
|Condition or disease||Intervention/treatment|
|Acute Myelogenous Leukemia||Device: 3 Tesla (3T) Siemens Total imaging matrix (TIM) Trio whole-body system|
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Quantitative DCE-MRI as a Predictor of Therapeutic Response in Acute Leukemia|
|Study Start Date :||May 2012|
|Estimated Primary Completion Date :||December 31, 2018|
|Estimated Study Completion Date :||December 31, 2018|
Acute Myelogenous Leukemia (AML)
Patients who have been diagnosed with AML
Device: 3 Tesla (3T) Siemens Total imaging matrix (TIM) Trio whole-body system
Each MR scanning session will include the pre-contrast multi-slice T2-weighted MRI with fat-saturation and T1-weighted MRI which are regularly acquired in clinical protocols. Following these acquisitions, high-spatial and temporal-resolution DCE-MRI will be performed. The total duration of a research MR session is expected to be less than 45 min.
Other Name: Magnetic Resonance Imaging (MRI)
- Shutter-Speed Model [ Time Frame: Up to 1 year ]To explore if Shutter-Speed Model (SSM) dynamic contrast-enhanced MRI (DCE-MRI)of the bone marrow (BM) can predict complete remission (CR) in newly diagnosed or relapsed acute myelogenous leukemia (AML)patients.
- Pilot Data [ Time Frame: Up to 1 year ]To collect pilot data in SSM DCE-MRI assessment of AML response to therapy for the conduct of future studies.
- Complete Response [ Time Frame: Up to 1 year ]To explore whether SSM DCE-MRI differs in predicting complete response (CR) for the newly diagnosed AML patients and for the relapsed AML patients.
- Second SSM DCE-MRI [ Time Frame: Up to 1 year ]To explore if the second SSM DCE-MRI and/or changes between the first and second imaging studies can predict CR in the non-CR group who undergo an additional therapy.
- DCE-MRI Biomarkers [ Time Frame: Up to 1 year ]To compare/correlate/combine DCE-MRI bio-markers with micro-vascular density (MVD) and proangiogenic cytokine profiles for the purpose of predicting response of AML patients to therapy.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01537159
|Contact: Alina Tudoricafirstname.lastname@example.org|
|United States, Oregon|
|Oregon Health and Science University||Recruiting|
|Portland, Oregon, United States, 97239|
|Contact: Alina Tudorica email@example.com|
|Principal Investigator: Wei Huang, PhD|
|Principal Investigator:||Wei Huang, PhD||OHSU Knight Cancer Institute|