HIV Accelerated Liver Disease in Uganda
|ClinicalTrials.gov Identifier: NCT01524562|
Recruitment Status : Completed
First Posted : February 2, 2012
Last Update Posted : April 5, 2018
- Liver disease is a leading cause of death in people who have the human immunodeficiency virus (HIV). It especially affects those who have both HIV and hepatitis B or C viruses. Most research on HIV-related liver disease has been conducted in North America and Europe. However, HIV-related liver disease in Uganda and other African nations may involve other diseases that are not common in the West, and may not involve hepatitis B or C. Researchers want to study HIV-related liver disease in Uganda to learn more about the differences between Western and African trends of this disease.
- To study HIV-related liver disease in rural Uganda.
- Individuals at least 18 years of age who were tested for possible liver disease. Some participants will have HIV infection; others will be uninfected.
- All participants will be from rural areas of Uganda.
- Participants will have at least two study visits.
- Participants will have a physical exam and medical history. They will complete a questionnaire about health and quality of life. Blood, urine, and stool samples will be collected. Participants will also have a liver scan to check for liver scarring, and an ultrasound to take images of the liver.
- Participants who may have liver disease will visit a local hospital for more tests. A liver biopsy will be performed to collect liver tissue samples.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||786 participants|
|Official Title:||HIV-Accelerated Liver Disease in Uganda|
|Study Start Date :||December 20, 2011|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01524562
|United States, Maryland|
|National Institute of Allergy and Infectious Diseases (NIAID), 9000 Rockville Pi|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Steven J Reynolds, M.D.||National Institute of Allergy and Infectious Diseases (NIAID)|