Steroid Treatment for Hypereosinophilic Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01524536
Recruitment Status : Recruiting
First Posted : February 2, 2012
Last Update Posted : January 15, 2019
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) )

Brief Summary:


- Hypereosinophilic syndrome (HES) is a disorder in which the body has too many eosinophils (a type of white blood cell). Too many eosinophils in HES can cause damage to the heart, nerves, or skin. Certain drugs can help lower eosinophil counts to prevent tissue damage. Corticosteroids, such as prednisone, are used for initial therapy in this disorder. Although most people respond to prednisone, some people develop side effects from it, or do not respond very well to treatment. Better ways of determining the dose to give could help to decide on the best therapy for HES.


  • To determine whether a single-dose of prednisone can be used to predict which people with hypereosinophilia respond to treatment.
  • To study lack of response to steroid treatment in people with HES.


Inclusion criteria:

  • Individuals with hypereosinophilic syndrome with high eosinophil counts.
  • Individuals who are willing to have blood drawn before and after getting steroids.

Exclusion criteria:

  • Individuals who are on more than 10mg of prednisone (or similar drug)
  • Individuals with hypereosinophilic syndrome who are on other medications that could interfere with the study
  • Women who are pregnant or breast-feeding
  • Individuals who have a known gene mutation associated with chronic eosinophilic leukemia
  • Children less than 18 years old who weigh less than 48kg or 106lb


  • Participants will have a screening visit with a physical exam and medical history. Blood and urine samples will be collected.
  • Participants will have a single dose of the steroid prednisone by mouth in the morning. Blood samples will be collected 2, 4, 24 hours after this dose.
  • On the day after the steroid dose, participants will provide another blood sample in the morning.
  • Participants will start to take prednisone daily when they return home. Blood samples will be collected weekly at the participant s doctor s office. The dose of prednisone will be lowered depending on the weekly eosinophil count. We will try to get each person on the lowest dose of prednisone possible that will control the disorder. Participants who do not respond or have severe side effects will be taken off prednisone. Other treatments will be considered for people who do not respond to steroids. The goal is to evaluate the response to prednisone. Our research will try to figure out why some people do not respond to steroids. Most people will complete the study within 6 to 16 weeks, depending on their response to prednisone.

Condition or disease Intervention/treatment Phase
Hypereosinophilia Drug: Corticosteroids Phase 4

Detailed Description:
This study aims to develop a model to determine whether a single, oral, weight-based dose of glucocorticoid (GC) can predict clinical and biologic response to GC s over the long term in subjects with hypereosinophilic syndrome (HES). Subjects with FIP1L1/PDGFRA-negative HES, who are symptomatic with eosinophil count >1500/microL and receiving less than or equal to10 mg prednisone daily, will be enrolled. A single oral dose of prednisone (1 mg/kg rounded to the nearest 5mg) will be administered. Eosinophil count and various laboratory parameters will be assessed at 2 hours, 4 hours and 24 hours following prednisone administration (investigators will be blinded to the results of the eosinophil counts). The subjects will then begin GC therapy at 30 mg prednisone daily followed by a standardized taper. The lowest dose of GC at which symptoms and eosinophilia are controlled will be compared to the change in eosinophil count at 2, 4 and 24 hours post-challenge. Mechanisms and in vitro correlates of GC resistance will also be explored.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Assessment of Glucocorticoid Responsiveness and Mechanisms of Resistance in Hypereosinophilic Syndromes
Study Start Date : November 23, 2011
Estimated Primary Completion Date : December 31, 2021
Estimated Study Completion Date : December 31, 2021

Primary Outcome Measures :
  1. To develop a model to determine whether a single dose steroid challenge can be used to predict GC responsiveness in subjects with HES [ Time Frame: completion of Study ]

Secondary Outcome Measures :
  1. To define a group of GC non-responders and/or suboptimal responders for further study of the mechanisms and biologic correlates of GC resistance in HES [ Time Frame: 7-24 weeks post challenge. ]
  2. To delineate some of the mechanisms of decreased GC responsiveness in GC-resistant subjects and to assess in-vitro correlates of therapeutic responsiveness in HES [ Time Frame: After a sufficient amount of patients from each patient typed has been enrolled and completed steroid taper ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   7 Years to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Subjects on Protocol #94-I-0079 will be eligible for participation in the study only if all of the following criteria apply:

  1. Subject meets diagnostic criteria for HES (AEC >1500/microL, absence of a secondary cause and signs and/or symptoms attributable to the eosinophilia)
  2. Willingness to perform the timed steroid challenge
  3. Appropriate candidate for GC treatment after challenge
  4. Willingness to have samples stored for future research


A subject will not be eligible to participate in the study if any of the following apply:

  1. Receiving >10 mg prednisone or equivalent at the time of enrollment.
  2. Receiving less than or equal to 10 mg of prednisone or equivalent but have not been on a fixed dose for at least 3 weeks (subjects on a current corticosteroid taper will be excluded).
  3. AEC less than or equal to 1500/microl at the time of enrollment.
  4. Use of immunomodulatory medications, (other than less than or equal to 10 mg/day prednisone) including but not limited to biologics, within the past 6 months.
  5. Pregnant at the time of evaluation.
  6. Have a known mutation in the FIP1L1-PDGFR gene.
  7. Any condition that, in the opinion of the investigator, places the subject at undue risk by participating in the protocol.
  8. Weight less than 48 kg (106 lbs) in subjects less than 18 years of age.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01524536

Contact: Nicole C Holland-Thomas, R.N. (301) 402-5969
Contact: Paneez Khoury, M.D. (301) 402-3673

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)    800-411-1222 ext TTY8664111010   
Sponsors and Collaborators
National Institute of Allergy and Infectious Diseases (NIAID)
Principal Investigator: Paneez Khoury, M.D. National Institute of Allergy and Infectious Diseases (NIAID)

Additional Information:
Responsible Party: National Institute of Allergy and Infectious Diseases (NIAID) Identifier: NCT01524536     History of Changes
Other Study ID Numbers: 120026
First Posted: February 2, 2012    Key Record Dates
Last Update Posted: January 15, 2019
Last Verified: January 11, 2019

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ):
Hypereosinophilic Syndrome

Additional relevant MeSH terms:
Hypereosinophilic Syndrome
Leukocyte Disorders
Hematologic Diseases