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Procalcitonin Monitoring Sepsis Study (MOSES)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01523717
Recruitment Status : Completed
First Posted : February 1, 2012
Last Update Posted : March 17, 2015
Information provided by (Responsible Party):
Brahms AG

Brief Summary:
The purpose of this study is to investigate the relationship between a procalcitonin decrease over 72 hours and outcome in patients who have severe sepsis or septic shock.

Condition or disease
Severe Sepsis Septic Shock

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Study Type : Observational
Actual Enrollment : 858 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Procalcitonin Decrease Over 72 Hours and Outcome in Patients With Severe Sepsis or Septic Shock
Study Start Date : December 2011
Actual Primary Completion Date : March 2014
Actual Study Completion Date : March 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sepsis Shock

Primary Outcome Measures :
  1. 28 day all cause mortality [ Time Frame: within 28 day safter inlclusion ]
    participants will be followed up for 28 days

Secondary Outcome Measures :
  1. all-cause in-hospital mortality [ Time Frame: mortality during hospital stay ]
    count all death through out stay in the hospital

Biospecimen Retention:   Samples Without DNA
EDTA plasma and serum samples

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
adult patients with severe sepsis or septic shock in the emergency department, medical floor, ICU

Inclusion Criteria:

  • Adult patients (i.e. >18 years of age) diagnosed with severe sepsis or septic shock as defined in Appendix 1, who are already in the ICU or come from the ED, other wards or directly from out of hospital
  • Blood sample collection within 12 hours after diagnosis "severe sepsis or septic shock"No prior enrollment into this study
  • Written informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01523717

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United States, California
University of California Davis Health System
Sacramento, California, United States, 95817
United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
United States, Massachusetts
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Saint Vincent Hospital
Worcester, Massachusetts, United States, 01608
United States, Michigan
Detroit Receiving Hospital
Detroit, Michigan, United States, 48201
Sinai Grace Hospital
Detroit, Michigan, United States, 48201
Henry Ford Health System
Detroit, Michigan, United States, 48202
United States, Mississippi
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
United States, New York
New York Methodist Hospital
New York, New York, United States, 11215
Stony Brook University
New York, New York, United States, 11794
United States, North Carolina
Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
United States, Pennsylvania
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
Brahms AG
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Principal Investigator: Nathan Shapiro, MD Beth Israel Deaconess Medical Center
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Responsible Party: Brahms AG Identifier: NCT01523717    
Other Study ID Numbers: brahms-moses
First Posted: February 1, 2012    Key Record Dates
Last Update Posted: March 17, 2015
Last Verified: March 2015
Keywords provided by Brahms AG:
decrease over 72 hours
severe sepsis
septic shock
Additional relevant MeSH terms:
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Shock, Septic
Systemic Inflammatory Response Syndrome
Pathologic Processes