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Cognitive Training for Patients With Schizophrenia

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ClinicalTrials.gov Identifier: NCT01521026
Recruitment Status : Completed
First Posted : January 30, 2012
Results First Posted : December 11, 2013
Last Update Posted : December 11, 2013
Sponsor:
Collaborator:
National Alliance for Research on Schizophrenia and Depression
Information provided by (Responsible Party):
ETwamley, University of California, San Diego

Brief Summary:

This research on cognitive training addresses the following questions:

  1. Does cognitive training lead to improved cognition, functional abilities, psychiatric symptoms, treatment adherence, or quality of life in patients with psychoses?
  2. What are the neurocognitive and non-cognitive factors that predict good outcomes following cognitive rehabilitation? In addition to verbal learning and memory, immediate verbal memory, vigilance, and executive functioning, the cognitive training intervention attempted to improve prospective memory ability (i.e., the ability to remember to do things in the future, such as take medications or attend a doctor's appointment).

Condition or disease Intervention/treatment Phase
Schizophrenia Schizoaffective Disorder Other Primary Psychotic Disorders Behavioral: Cognitive Training Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 69 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Cognitive Training for Patients With Schizophrenia
Study Start Date : September 2003
Actual Primary Completion Date : August 2009
Actual Study Completion Date : August 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia
U.S. FDA Resources

Arm Intervention/treatment
Experimental: Cognitive Training
Cognitive training group
Behavioral: Cognitive Training
12-week compensatory cognitive training in group format
No Intervention: Standard Pharmacotherapy



Primary Outcome Measures :
  1. UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) [ Time Frame: 3 months ]
    Performance-based measure of functional capacity in five domains: Communication, Finance, Recreation Planning, Transportation, and Household Chores Scale ranges from 0-100. Subscales are summed to yield the total score. Higher scores represent better performance.


Secondary Outcome Measures :
  1. Hopkins Verbal Learning Test Percent Retained [ Time Frame: 3 months ]

    Verbal list learning task with three learning trials and a delay trial. Percent retained refers to the percentage of items recalled at the delay trial, compared to the third learning trial.

    Score ranges from 0-100. Higher scores represent better performance.




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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Primary psychotic disorder (including schizophrenia, schizoaffective disorder, psychotic mood disorder, or psychosis NOS)
  • Age 18 or older
  • Fluency in English

Exclusion Criteria:

  • Dementia
  • Neurological conditions affecting cognition
  • Mental retardation
  • Substance use disorder within the past month
  • Participation in other intervention trials

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01521026


Locations
United States, California
UCSD Outpatient Psychiatric Services
San Diego, California, United States, 92103
Sponsors and Collaborators
University of California, San Diego
National Alliance for Research on Schizophrenia and Depression
Investigators
Principal Investigator: Elizabeth W Twamley, PhD UCSD

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: ETwamley, Associate Professor of Psychiatry, University of California, San Diego
ClinicalTrials.gov Identifier: NCT01521026     History of Changes
Other Study ID Numbers: NARSAD Young Investigator
First Posted: January 30, 2012    Key Record Dates
Results First Posted: December 11, 2013
Last Update Posted: December 11, 2013
Last Verified: November 2013

Additional relevant MeSH terms:
Disease
Schizophrenia
Psychotic Disorders
Mental Disorders
Pathologic Processes
Schizophrenia Spectrum and Other Psychotic Disorders