Biomarkers in Samples From Patients With B-Cell Acute Lymphoblastic Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in samples from patients with acute lymphoblastic leukemia enrolled on ECOG-2993 clinical trial.
|Leukemia||Genetic: RNA analysis Genetic: cytogenetic analysis Genetic: microarray analysis Other: laboratory biomarker analysis|
|Study Design:||Observational Model: Other
Time Perspective: Retrospective
|Official Title:||Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities|
- Comprehensive view of microRNA expression by cytogenetic subgroup [ Time Frame: 1 year ]
- MicroRNA expression in relation to clinical outcome [ Time Frame: 1 year ]
- Differential microRNA expression between normal B-cells and progenitors compared to B-ALL [ Time Frame: 1 year ]
|Actual Study Start Date:||January 6, 2012|
|Study Completion Date:||February 6, 2012|
|Primary Completion Date:||February 6, 2012 (Final data collection date for primary outcome measure)|
- To identify microRNAs that behave as oncogenes or as tumor suppressor genes in B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo.
- To examine if single microRNA or signatures of microRNA correspond to different clinical outcomes in cytogenetically distinct B-ALL groups.
OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and in vivo.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01505699
|Principal Investigator:||Hans-Guido Wendel, MD||Memorial Sloan Kettering Cancer Center|