High Intensity Strength Training & Bone Mineral Density in Young Women
|ClinicalTrials.gov Identifier: NCT01482130|
Recruitment Status : Completed
First Posted : November 30, 2011
Last Update Posted : August 1, 2016
|Condition or disease||Intervention/treatment||Phase|
|Osteoporosis||Behavioral: Heavy, explosive strength training Behavioral: recommendations||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Preventing Osteoporosis: The Effect of High Intensity Strength Training on Bone Mineral Density in Young and Healthy Women|
|Study Start Date :||November 2011|
|Actual Primary Completion Date :||April 2012|
|Actual Study Completion Date :||June 2012|
Experimental: Training group
All participants in the training group will pursue a 12 weeks of strength training.
Behavioral: Heavy, explosive strength training
All participants of the training group will pursue a 12 weeks of heavy, explosive strength training, 3 sessions a week for a total of 36 sessions. The training session will include one squat exercise only, which allows muscle contraction of the quadriceps from a 90° bend at the knees to straight legs.
The control group will be encouraged to follow a training program according to recommended exercise guidelines
The control group will be encouraged to follow a training program according to recommended exercise guidelines:
- Bone mineral density [ Time Frame: Baseline and 12 weeks ](Dual X-ray Absorptiometry)
- Serum markers of bone metabolism [ Time Frame: Baseline and 12 weeks ]Blood samples will be drawn for analyses of bone metabolism and markers of bone formation; osteoprotegerin (OPG) and Type I procollagen N-terminal propeptide (PINP). Furthermore, Type 1 collagen C-breakdown products (CTX) and receptor activator of NF kappa B ligand (RANKL) which are the key regulators of bone resorption, will be analyzed at the start and end of the study.
- Body composition [ Time Frame: Baseline and 12 weeks ]Lean- versus fat mass, measured by Dual X-ray Absorptiometry (DXA).
- Maximal muscle strength [ Time Frame: Baseline and 12 weeks ]Measured as one repetition maximum in a squat exercise machine.
- Rate of force development [ Time Frame: Baseline and 12 weeks ]Maesured dynamic in a squat exercise maschine, and isometric at 90 degree angle in the knee joint.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01482130
|Norwegian University of Science and Technology|
|Trondheim, Sor.tronderlag, Norway, 7030|
|Study Director:||Unni Syversen, MD, PhD||Norwegian University of Science and Technology|