PEEP Recruitment-comparison Between Ultrasonographic Assessment and LIP Assessment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01478217
Recruitment Status : Completed
First Posted : November 23, 2011
Last Update Posted : November 23, 2011
Information provided by (Responsible Party):
Bojan Rode, Sisters of Mercy University Hospital

Brief Summary:
The purpose of this study is to compare lung recruitment in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) based on lower inflection point with transthoracic ultrasonographic assessment of lung recruitment.

Condition or disease
Acute Respiratory Distress Syndrome

Detailed Description:

Sedated and sometimes temporary relaxed patients with ALI/ARDS on mechanical ventilation in semirecumbent position are included. Lower inflection point on pressure volume loop on ventilator Draeger Evita 4 with low continuous flow on volume controlled ventilation is measured with zero PEEP. Transthoracic lung ultrasound with linear probe is proceed on both hemithoraces when mechanical ventilation based on measured PEEP is started. We compare if real lung recruitment seen by ultrasound is the same as predicted by lower inflection point.

The procedure is a part of routine everyday respiratory monitoring in our unit.

Study Type : Observational
Actual Enrollment : 17 participants
Observational Model: Case Control
Official Title: Positive End-expiratory Pressure Induced Lung Recruitment -Comparison Between Ultrasonographic Assessment and Lower Inflection Point Assessment on the Pressure -Volume Loop
Study Start Date : October 2009
Actual Primary Completion Date : November 2011
Actual Study Completion Date : November 2011

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
intensive care patients

Inclusion Criteria:

  • patients with diffuse ALI/ARDS on mechanical ventilation with visible lower inflection point on dynamic P-V loops

Exclusion Criteria:

  • preexisting parenchymal or pleural lung disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01478217

Central intensive care unit, University hospital "Sisters of Mercy"
Grad Zagreb, Croatia, 10000
Sponsors and Collaborators
Sisters of Mercy University Hospital
Principal Investigator: Bojan Rode, M.D.

Publications of Results:
Responsible Party: Bojan Rode,, Sisters of Mercy University Hospital Identifier: NCT01478217     History of Changes
Other Study ID Numbers: Vinogradska29
First Posted: November 23, 2011    Key Record Dates
Last Update Posted: November 23, 2011
Last Verified: November 2011

Keywords provided by Bojan Rode, Sisters of Mercy University Hospital:
lung ultrasonography
pressure-volume loops

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury