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Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients

This study has been completed.
Fundação de Amparo à Pesquisa do Estado de São Paulo
Information provided by (Responsible Party):
FLAVIA SOARES MACHADO, Federal University of São Paulo Identifier:
First received: November 18, 2011
Last updated: NA
Last verified: November 2011
History: No changes posted
The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of rheumatoid arthritis.

Disorders of Synovium, Multiple Sites Disorders of Subchondral Bone, Multiple Sites Disorders of Cartilage, Hand Joints Arthritis, Rheumatoid Healthy People

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Articular Sonography: Findings in Healthy Subjects Compared With Rheumatoid Arthritis Patients

Resource links provided by NLM:

Further study details as provided by FLAVIA SOARES MACHADO, Federal University of São Paulo:

Biospecimen Retention:   Samples With DNA

Enrollment: 190
Study Start Date: March 2010
Study Completion Date: June 2011
Primary Completion Date: June 2011 (Final data collection date for primary outcome measure)
normal, healthy people
rheumatoid arthritis patients

Detailed Description:
Rheumatoid arthritis (RA) is a chronic inflammatory, systemic and auto-imune disorder affecting primarily the joints. In RA, inflammatory synovium causes destruction of cartilage, erosion of the adjacent bone and ultimately loss of function of the affected joint. Newer imaging techniques, such as ultrasound (US), have shown promise in evaluation of RA. Many US scoring system have been used to classify and quantify the synovium, effusion, erosion and cartilage for assessing and monitoring AR. However, its use is considered problematical because there are very few data on normal joints and, at this point, there is no clear definition of excess amount of synovium in normal people.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
terciary care clinic (rheumatoid arthritis patients) community sample (healthy people)

Inclusion Criteria:

  • no articular disease (healthy group)
  • establish rheumatoid arthritis (RA group)

Exclusion Criteria:

  • diabetes
  • hypothyroidism- hemophilia
  • pregnancy
  • previous septic arthritis
  • previous articular surgery
  • symptomatic osteoarthritis
  • no superimposed collagenoses (RA group)
  Contacts and Locations
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Please refer to this study by its identifier: NCT01476865

Sponsors and Collaborators
Federal University of São Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo
Study Chair: Jamil Natour, professor Federal University of São Paulo
Study Chair: Rita NV Furtado, PhD Federal University of São Paulo
Principal Investigator: Flávia S Machado, master Federal University of São Paulo
  More Information

Responsible Party: FLAVIA SOARES MACHADO, Flávia Soares Machado, Federal University of São Paulo Identifier: NCT01476865     History of Changes
Other Study ID Numbers: 1295/09
Study First Received: November 18, 2011
Last Updated: November 18, 2011

Additional relevant MeSH terms:
Arthritis, Rheumatoid
Cartilage Diseases
Pathologic Processes
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases processed this record on September 21, 2017